Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock

Histone lysine (K) residues, which are modified by methyl- and acetyl-transferases, diversely regulate RNA synthesis. Unlike the ubiquitously activating effect of histone K acetylation, the effects of histone K methylation vary with the number of methyl groups added and with the position of these gr...

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Veröffentlicht in:	PLoS biology 2014-12, Vol.12 (12), p.e1002026-e1002026
Hauptverfasser:	Cheng, Mo-bin, Zhang, Yan, Cao, Chun-yu, Zhang, Wei-long, Zhang, Ye, Shen, Yu-fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biology and life sciences Chromatin Assembly and Disassembly - drug effects Chromatin Assembly and Disassembly - genetics Gene expression Gene Expression Regulation - drug effects Genome, Human Genomes Health aspects Heat shock proteins Heat-Shock Response - drug effects Heat-Shock Response - genetics Histones HSP90 Heat-Shock Proteins - metabolism Humans Interferon-gamma - pharmacology Jumonji Domain-Containing Histone Demethylases - chemistry Jumonji Domain-Containing Histone Demethylases - metabolism Jurkat Cells Kinases Metabolism Models, Biological Molecular Sequence Data Phosphorylation Phosphorylation - drug effects Phosphoserine - metabolism Protein Binding - drug effects Protein research Proteins Ribosomal Protein S6 Kinases, 90-kDa - metabolism Signal Transduction - drug effects Signal Transduction - genetics Spermatogenesis STAT1 Transcription Factor - metabolism Stress, Physiological - drug effects Stress, Physiological - genetics Transcription factors
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