Structure of a membrane-embedded prenyltransferase homologous to UBIAD1

Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport, including Vitamin K and Coenzyme Q. In humans, missens...

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Veröffentlicht in:	PLoS Biol 2014-07, Vol.12 (7), p.e1001911-e1001911
Hauptverfasser:	Huang, Hua, Levin, Elena J, Liu, Shian, Bai, Yonghong, Lockless, Steve W, Zhou, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Archaeoglobus fulgidus - enzymology Biology and Life Sciences Biosynthesis Catalytic Domain Cell Membrane - enzymology Crystallography, X-Ray Data collection Dimethylallyltranstransferase - chemistry Dimethylallyltranstransferase - genetics E coli Experiments Humans Magnesium - chemistry Membranes Models, Molecular Mutation Physiological aspects Protein Binding Protein research Protein-protein interactions Proteins Sequence Homology, Amino Acid Transferases Vitamin K
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