Amino Acid Substitutions Improve the Immunogenicity of H7N7HA Protein and Protect Mice against Lethal H7N7 Viral Challenge

Avian influenza A H7N7/NL/219/03 virus creates a serious pandemic threat to human health because it can transmit directly from domestic poultry to humans and from human to human. Our previous vaccine study reported that mice when immunized intranasally (i.n) with live Bac-HA were protected from leth...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0128940
Hauptverfasser:	Kumar, Subaschandrabose Rajesh, Prabakaran, Mookkan, Ashok Raj, Kattur Venkatachalam, He, Fang, Kwang, Jimmy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Amino Acid Substitution - immunology Amino acids Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Formation - immunology Avian flu Avian influenza Baculovirus Binding sites Biotechnology Cell Line Cytotoxicity Female HA protein Health aspects Health risks Hemagglutination inhibition Immunization Immunization - methods Immunogenicity Influenza Influenza A Influenza A Virus, H7N7 Subtype - immunology Influenza A Virus, H7N9 Subtype - immunology Influenza Vaccines - immunology Low level Lungs Medical laboratories Mice Mice, Inbred BALB C Mutagenesis Neutralization Occupational accidents Orthomyxoviridae Infections - immunology Pandemics Peptides Proteins Sf9 Cells Site-directed mutagenesis Spodoptera Vaccination Vaccination - methods Vaccines Viruses
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