Thyroid Hormone Receptors Predict Prognosis in BRCA1 Associated Breast Cancer in Opposing Ways

Since BRCA1 associated breast cancers are frequently classified as hormone receptor negative or even triple negative, the application of endocrine therapies is rather limited in these patients. Like hormone receptors that bind to estrogen or progesterone, thyroid hormone receptors (TRs) are members...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0127072-e0127072
Hauptverfasser:	Heublein, Sabine, Mayr, Doris, Meindl, Alfons, Angele, Martin, Gallwas, Julia, Jeschke, Udo, Ditsch, Nina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers BRCA1 protein BRCA1 Protein - metabolism Breast cancer Breast Neoplasms - blood Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell cycle Cell Line, Tumor Cohort Studies Endocrine therapy Endocrinology Estrogens Female Gene expression Gynecology Health risk assessment Hormones Humans Immunohistochemistry Lymphatic system Medical diagnosis Medical prognosis Metastasis Middle Aged Mutation Obstetrics Patients Progesterone Prognosis Proteins Receptors Receptors, Thyroid Hormone - metabolism Surgery Survival Thyroid Thyroid gland Thyroid hormone receptors Thyroxine - blood Triiodothyronine Triiodothyronine - blood Triiodothyronine - pharmacology Tumorigenesis Tumors Ubiquitin - metabolism
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