Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma

β2-adrenergic receptor (β2AR) agonists (β2-agonist) are the most commonly used therapy for acute relief in asthma, but chronic use of these bronchodilators paradoxically exacerbates airway hyper-responsiveness. Activation of βARs by β-agonist leads to desensitization (inactivation) by phosphorylatio...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125803-e0125803
Hauptverfasser:	Gupta, Manveen K, Asosingh, Kewal, Aronica, Mark, Comhair, Suzy, Cao, Gaoyuan, Erzurum, Serpil, Panettieri, Jr, Reynold A, Naga Prasad, Sathyamangla V
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adrenergic receptors Airway management Arrestin Asthma Asthma - metabolism Asthma - physiopathology Bronchodilators Cardiology Cell Membrane - metabolism Cells, Cultured Chronic obstructive pulmonary disease Confocal Confocal microscopy Critical care Cyclic AMP - metabolism Deactivation Defects Dephosphorylation Desensitization Endosomes Endosomes - metabolism Family medical history G protein-coupled receptors Homeostasis Humans Immunoblotting Immunoprecipitation Inactivation Internalization Kinases Lungs Microscopy Microscopy, Confocal Muscles Myocytes, Smooth Muscle - cytology Pathology Phosphatase Phosphorylation Proteins Receptors Receptors, Adrenergic, beta-2 - metabolism Reduction Respiratory System - cytology Respiratory tract Smooth muscle Studies
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