Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis

Dietary vitamin D3 (D3) restriction reduces paw grip endurance and motor performance in G93A mice, and increases inflammation and apoptosis in the quadríceps of females. ALS, a neuromuscular disease, causes progressive degeneration of motor neurons in the brain and spinal cord. We analyzed the spina...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126355-e0126355
Hauptverfasser:	Moghimi, Elnaz, Solomon, Jesse A, Gianforcaro, Alexandro, Hamadeh, Mazen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Animals Antioxidants Apoptosis BAX protein Bcl-2 protein Biomarkers Brain Caspase Caspase-3 Catalase Cholecalciferol - deficiency Degeneration Dementia Diet Disease Endurance Feeds Female Females Gender differences Glial cell line-derived neurotrophic factor Inflammation Interleukin 10 Interleukin 6 Kinesiology Laboratories Male Males Medical research Mice Mice, Transgenic Motor neurons Motor task performance Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegeneration Nutrient content Nutrition research Oxidative stress Proteins Quadriceps muscle Rodents Spinal cord Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord - physiopathology Studies Superoxide dismutase Tumor necrosis factor-α Vitamin D Vitamin D3 Vitamin deficiency
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