Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure

Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are lacking. MicroRNAs are short, non-coding strand...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0128076-e0128076
Hauptverfasser:	Baker, Luisa A, Lee, Karla C L, Palacios Jimenez, Carolina, Alibhai, Hatim, Chang, Yu-Mei, Leckie, Pamela J, Mookerjee, Rajeshwar P, Davies, Nathan A, Andreola, Fausto, Jalan, Rajiv
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - adverse effects Analgesics Analysis Animals Biomarkers Brain Brain injury Catastrophic failure analysis Chemical and Drug Induced Liver Injury - blood Coding Complications and side effects Creatinine Damage detection Damage patterns Deoxyribonucleic acid Diagnosis Disease Disease Models, Animal DNA Dosage and administration Exosomes Genetic aspects Head injuries Hospitals Intracranial pressure Intracranial Pressure - drug effects Kidneys Liver Liver diseases Liver failure Liver Failure, Acute - blood Liver Failure, Acute - chemically induced Medical prognosis Medical schools MicroRNA MicroRNAs MicroRNAs - blood miRNA Non-coding RNA Perfusion Physiological aspects Plasma Plasma levels Pressure Ribonucleic acid RNA Rodents Science Studies Swine Traumatic brain injury Veterinary colleges
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