Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis

A hallmark of regulatory B cells is IL-10 production, hence their designation as IL-10+ B cells. Little is known about the ability of self-antigens to induce IL-10+ B cells in Graves' disease (GD), Hashimoto's thyroiditis (HT), or other autoimmune disease. Here we pulsed purified B cells f...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0127949-e0127949
Hauptverfasser:	Kristensen, Birte, Hegedüs, Laszlo, Lundy, Steven K, Brimnes, Marie K, Smith, Terry J, Nielsen, Claus H
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - immunology Adult Aged Antigens Arthritis Autoantigens Autoimmune Diseases - immunology Autoimmune thyroiditis B cells B-Lymphocytes, Regulatory - immunology Case-Control Studies CD24 Antigen - immunology CD25 antigen CD27 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD43 antigen Cell differentiation Cell surface Cytokines Development and progression Diabetes Endocrinology Female Graves Disease - immunology Graves' disease Hashimoto Disease - immunology Hepatitis A Virus Cellular Receptor 1 Hospitals Humans Infectious diseases Inflammation Interleukin 10 Interleukin-10 - immunology Interleukin-2 Receptor alpha Subunit - immunology Internal medicine Ionomycin Laboratory tests Leukocytes (mononuclear) Ligands Lymphocyte receptors Lymphocytes Lymphocytes B Lymphocytes T Male Membrane Glycoproteins - immunology Metabolism Middle Aged Patients Peripheral blood mononuclear cells Physiological aspects Receptors, Virus - immunology Rheumatology Surface markers T cell receptors Thyroglobulin Thyroglobulin - immunology Thyroid Thyroid gland Thyroid Gland - immunology Thyroiditis Triiodothyronine
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