AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic

The cell surface proteome controls numerous cellular functions including cell migration and adhesion, intercellular communication and nutrient uptake. Cell surface proteins are controlled by acute changes in protein abundance at the plasma membrane through regulation of endocytosis and recycling (en...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0128013-e0128013
Hauptverfasser:	Ross, Eden, Ata, Rehman, Thavarajah, Thanusi, Medvedev, Sergei, Bowden, Peter, Marshall, John G, Antonescu, Costin N
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Adhesion AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Biotinylation Cell adhesion & migration Cell Adhesion - drug effects Cell interactions Cell Line Cell Membrane - metabolism Cell migration Cell Movement - drug effects Cell signaling Cell surface Control Endocytosis Energy expenditure Energy intake Gene Expression Regulation Gene silencing Genetic engineering Glucose Humans Integrins Integrins - metabolism Intercellular signalling Kinases Mass Spectrometry Mass spectroscopy Membrane trafficking Nutrient uptake Physiological aspects Protein kinases Protein Transport - drug effects Protein turnover Proteins Proteome - drug effects Proteome - metabolism Proteomes Pyrones - pharmacology Rodents Thiophenes - pharmacology Traffic Transferrin Transferrins
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