Sequential FOLFIRI.3 + Gemcitabine Improves Health-Related Quality of Life Deterioration-Free Survival of Patients with Metastatic Pancreatic Adenocarcinoma: A Randomized Phase II Trial

A randomized multicenter phase II trial was conducted to assess the sequential treatment strategy using FOLFIRI.3 and gemcitabine alternately (Arm 2) compared to gemcitabine alone (Arm 1) in patients with metastatic non pre-treated pancreatic adenocarcinoma. The primary endpoint was the progression-...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125350
Hauptverfasser:	Anota, Amélie, Mouillet, Guillaume, Trouilloud, Isabelle, Dupont-Gossart, Anne-Claire, Artru, Pascal, Lecomte, Thierry, Zaanan, Aziz, Gauthier, Mélanie, Fein, Francine, Dubreuil, Olivier, Paget-Bailly, Sophie, Taieb, Julien, Bonnetain, Franck
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adult Aged Antimetabolites, Antineoplastic - therapeutic use Antineoplastic Combined Chemotherapy Protocols Breast cancer Cancer therapies Care and treatment Chemotherapy Clinical trials Comparative analysis Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Deterioration Drug therapy Female Gastroenterology Gemcitabine Global health Health aspects Health Status Humans Liver Neoplasms - drug therapy Liver Neoplasms - mortality Liver Neoplasms - psychology Liver Neoplasms - secondary Longitudinal Studies Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - psychology Lung Neoplasms - secondary Male Medical prognosis Metastases Metastasis Methods Middle Aged Missing data Multivariate Analysis Oncology Pain Pancreas Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - psychology Patient outcomes Patients Public health Quality of life Quality of Life - psychology Randomization Regression analysis Research Design Statistical analysis Studies Surveys and Questionnaires Survival Survival Analysis
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