CD36 Mediated Fatty Acid-Induced Podocyte Apoptosis via Oxidative Stress

Hyperlipidemia-induced apoptosis mediated by fatty acid translocase CD36 is associated with increased uptake of ox-LDL or fatty acid in macrophages, hepatocytes and proximal tubular epithelial cells, leading to atherosclerosis, liver damage and fibrosis in obese patients, and diabetic nephropathy (D...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0127507-e0127507
Hauptverfasser:	Hua, Wei, Huang, Hui-zhe, Tan, Lan-ting, Wan, Jiang-min, Gui, Hai-bo, Zhao, Liang, Ruan, Xiong-zhong, Chen, Xue-mei, Du, Xiao-gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens Antioxidants Apoptosis Apoptosis - drug effects Apoptosis - physiology Arteriosclerosis Atherosclerosis Binding sites CD36 antigen CD36 Antigens - genetics CD36 Antigens - metabolism Complications and side effects Cyclic N-Oxides - pharmacology Cytometry Cytoplasm Diabetes Diabetes mellitus Diabetic nephropathy Epithelial cells Fatty acids Fibrosis Flow cytometry Fluorescence Genetic aspects Hepatocytes Hospitals Humans Hyperlipidemia Immunofluorescence Immunohistochemistry Kidney - drug effects Kidney - metabolism Kidney diseases Kidneys Laboratories Lipids Liver Low density lipoprotein Macrophages Mice Nephrology Nephropathy Oleic Acids - pharmacology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Palmitic acid Palmitic Acid - pharmacology Patients Physiological aspects Podocytes - drug effects Podocytes - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Spin Labels Staining Statistical analysis Statistical methods Statistics Studies Succinimides - pharmacology Translocation
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