Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation

In some esophageal cancer patients, radiotherapy may not prevent distant metastasis thus resulting in poor survival. The underlying mechanism of metastasis in these patients is not well established. In this study, we have demonstrated that ionizing radiation may induce epithelial-mesenchymal transit...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126149-e0126149
Hauptverfasser:	He, Enhui, Pan, Fei, Li, Guangchao, Li, Jingjing
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation AKT protein Analysis Apoptosis Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Care and treatment Cell adhesion & migration Cell cycle Cell Line, Tumor Cell migration Cell Movement - radiation effects Cell survival Complications and side effects Development and progression Down-Regulation - radiation effects Drug dosages Enzyme inhibitors Epithelial-Mesenchymal Transition - radiation effects Esophageal cancer Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma Esophagus Genotype & phenotype Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Homology Hospitals Humans I.R. radiation Invasiveness Ionizing radiation Kinases Lung cancer Mesenchyme Metastases Metastasis Mortality Overexpression Patient outcomes Patients Physical characteristics Physiological aspects Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Radiation Radiation therapy Radiation, Ionizing Radioresistance Signal Transduction - radiation effects Signaling Snail protein Stem cells Survival Tensin Tumor cells
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