Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey
Little is known regarding the effects of environmental exposure of chemicals on androgenic system in the general population. We studied 5,107 subjects included in the National Health and Nutrition Examination Survey (2011-2012). Urinary, serum, and blood levels of 15 subclasses comprising 110 indivi...
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| description | Little is known regarding the effects of environmental exposure of chemicals on androgenic system in the general population. We studied 5,107 subjects included in the National Health and Nutrition Examination Survey (2011-2012).
Urinary, serum, and blood levels of 15 subclasses comprising 110 individual chemicals were analyzed for their association with serum testosterone levels. The subjects were divided into high and low testosterone groups according to the median testosterone concentration (374.51 ng/dL). Odds ratios (ORs) of individual chemicals in association with testosterone were estimated using logistic regression after adjusting for age, ethnicity, cotinine, body mass index, creatinine, alcohol, and the poverty income ratio.
Adjusted ORs for the highest versus lowest quartiles of exposure were 2.12 (95% CI: 1.07, 4.21; Ptrend = 0.044), 1.84 (95% CI: 1.02, 3.34; Ptrend = 0.018) for the association between urinary mandelic acid, and strontium quartiles with low testosterone concentrations in adult men, respectively. However, no association was observed for the remaining chemicals with testosterone.
The National Health and Nutrition Examination Survey data suggest that elevations in urinary mandelic acid, and strontium levels are negatively related to low serum testosterone levels in adult men. |
| doi_str_mv | 10.1371/journal.pone.0127451 |
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Urinary, serum, and blood levels of 15 subclasses comprising 110 individual chemicals were analyzed for their association with serum testosterone levels. The subjects were divided into high and low testosterone groups according to the median testosterone concentration (374.51 ng/dL). Odds ratios (ORs) of individual chemicals in association with testosterone were estimated using logistic regression after adjusting for age, ethnicity, cotinine, body mass index, creatinine, alcohol, and the poverty income ratio.
Adjusted ORs for the highest versus lowest quartiles of exposure were 2.12 (95% CI: 1.07, 4.21; Ptrend = 0.044), 1.84 (95% CI: 1.02, 3.34; Ptrend = 0.018) for the association between urinary mandelic acid, and strontium quartiles with low testosterone concentrations in adult men, respectively. However, no association was observed for the remaining chemicals with testosterone.
The National Health and Nutrition Examination Survey data suggest that elevations in urinary mandelic acid, and strontium levels are negatively related to low serum testosterone levels in adult men.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0127451</identifier><identifier>PMID: 25996772</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Adult ; Adults ; Aged ; Alcoholic beverages ; Androgens ; Arsenic ; Blood levels ; Body mass ; Body mass index ; Body size ; Chemicals ; Cotinine ; Creatinine ; Diabetes ; Disease control ; Drug dosages ; Education ; Environmental effects ; Environmental Exposure ; Environmental health ; Environmental Pollutants ; Epidemiology ; Ethnic Groups ; Exposure ; Food and nutrition ; Health aspects ; Health care ; Health sciences ; History, 21st Century ; Humans ; Laboratories ; Male ; Mandelic Acids - urine ; Measurement ; Medicine ; Men ; Mens health ; Metabolites ; Middle Aged ; Minority & ethnic groups ; Nutrition ; Nutrition Surveys ; Obesity ; Occupational health ; Odds Ratio ; Physiological aspects ; Population studies ; Poverty ; Public health ; Public Health Surveillance ; Quartiles ; Regression analysis ; Reproductive health ; Risk Factors ; Sperm ; Strontium ; Strontium - urine ; Studies ; Surveys ; Testosterone ; Testosterone - blood ; Trends ; United States - epidemiology ; Urine</subject><ispartof>PloS one, 2015-05, Vol.10 (5), p.e0127451-e0127451</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Xu et al 2015 Xu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3ef70f152b1cb4b990f02dff8ef456c02d6e12a76b5bbedced44ef86d10cc3443</citedby><cites>FETCH-LOGICAL-c692t-3ef70f152b1cb4b990f02dff8ef456c02d6e12a76b5bbedced44ef86d10cc3443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440739/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440739/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25996772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Cheng</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Liu, Hui</creatorcontrib><creatorcontrib>Héroux, Paul</creatorcontrib><creatorcontrib>Zhang, Qunwei</creatorcontrib><creatorcontrib>Jiang, Zhao-Yan</creatorcontrib><creatorcontrib>Gu, Aihua</creatorcontrib><title>Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Little is known regarding the effects of environmental exposure of chemicals on androgenic system in the general population. We studied 5,107 subjects included in the National Health and Nutrition Examination Survey (2011-2012).
Urinary, serum, and blood levels of 15 subclasses comprising 110 individual chemicals were analyzed for their association with serum testosterone levels. The subjects were divided into high and low testosterone groups according to the median testosterone concentration (374.51 ng/dL). Odds ratios (ORs) of individual chemicals in association with testosterone were estimated using logistic regression after adjusting for age, ethnicity, cotinine, body mass index, creatinine, alcohol, and the poverty income ratio.
Adjusted ORs for the highest versus lowest quartiles of exposure were 2.12 (95% CI: 1.07, 4.21; Ptrend = 0.044), 1.84 (95% CI: 1.02, 3.34; Ptrend = 0.018) for the association between urinary mandelic acid, and strontium quartiles with low testosterone concentrations in adult men, respectively. However, no association was observed for the remaining chemicals with testosterone.
The National Health and Nutrition Examination Survey data suggest that elevations in urinary mandelic acid, and strontium levels are negatively related to low serum testosterone levels in adult men.</description><subject>Acids</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Alcoholic beverages</subject><subject>Androgens</subject><subject>Arsenic</subject><subject>Blood levels</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Chemicals</subject><subject>Cotinine</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Disease control</subject><subject>Drug dosages</subject><subject>Education</subject><subject>Environmental effects</subject><subject>Environmental Exposure</subject><subject>Environmental health</subject><subject>Environmental Pollutants</subject><subject>Epidemiology</subject><subject>Ethnic Groups</subject><subject>Exposure</subject><subject>Food and nutrition</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Health sciences</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Mandelic Acids - urine</subject><subject>Measurement</subject><subject>Medicine</subject><subject>Men</subject><subject>Mens health</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Obesity</subject><subject>Occupational health</subject><subject>Odds Ratio</subject><subject>Physiological aspects</subject><subject>Population studies</subject><subject>Poverty</subject><subject>Public health</subject><subject>Public Health Surveillance</subject><subject>Quartiles</subject><subject>Regression analysis</subject><subject>Reproductive health</subject><subject>Risk Factors</subject><subject>Sperm</subject><subject>Strontium</subject><subject>Strontium - urine</subject><subject>Studies</subject><subject>Surveys</subject><subject>Testosterone</subject><subject>Testosterone - blood</subject><subject>Trends</subject><subject>United States - 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Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey</title><author>Xu, Cheng ; Liu, Qian ; Liu, Hui ; Héroux, Paul ; Zhang, Qunwei ; Jiang, Zhao-Yan ; Gu, Aihua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3ef70f152b1cb4b990f02dff8ef456c02d6e12a76b5bbedced44ef86d10cc3443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Alcoholic beverages</topic><topic>Androgens</topic><topic>Arsenic</topic><topic>Blood levels</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Chemicals</topic><topic>Cotinine</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Disease control</topic><topic>Drug 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Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-05-21</date><risdate>2015</risdate><volume>10</volume><issue>5</issue><spage>e0127451</spage><epage>e0127451</epage><pages>e0127451-e0127451</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Little is known regarding the effects of environmental exposure of chemicals on androgenic system in the general population. We studied 5,107 subjects included in the National Health and Nutrition Examination Survey (2011-2012).
Urinary, serum, and blood levels of 15 subclasses comprising 110 individual chemicals were analyzed for their association with serum testosterone levels. The subjects were divided into high and low testosterone groups according to the median testosterone concentration (374.51 ng/dL). Odds ratios (ORs) of individual chemicals in association with testosterone were estimated using logistic regression after adjusting for age, ethnicity, cotinine, body mass index, creatinine, alcohol, and the poverty income ratio.
Adjusted ORs for the highest versus lowest quartiles of exposure were 2.12 (95% CI: 1.07, 4.21; Ptrend = 0.044), 1.84 (95% CI: 1.02, 3.34; Ptrend = 0.018) for the association between urinary mandelic acid, and strontium quartiles with low testosterone concentrations in adult men, respectively. However, no association was observed for the remaining chemicals with testosterone.
The National Health and Nutrition Examination Survey data suggest that elevations in urinary mandelic acid, and strontium levels are negatively related to low serum testosterone levels in adult men.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25996772</pmid><doi>10.1371/journal.pone.0127451</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-05, Vol.10 (5), p.e0127451-e0127451 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Acids Adult Adults Aged Alcoholic beverages Androgens Arsenic Blood levels Body mass Body mass index Body size Chemicals Cotinine Creatinine Diabetes Disease control Drug dosages Education Environmental effects Environmental Exposure Environmental health Environmental Pollutants Epidemiology Ethnic Groups Exposure Food and nutrition Health aspects Health care Health sciences History, 21st Century Humans Laboratories Male Mandelic Acids - urine Measurement Medicine Men Mens health Metabolites Middle Aged Minority & ethnic groups Nutrition Nutrition Surveys Obesity Occupational health Odds Ratio Physiological aspects Population studies Poverty Public health Public Health Surveillance Quartiles Regression analysis Reproductive health Risk Factors Sperm Strontium Strontium - urine Studies Surveys Testosterone Testosterone - blood Trends United States - epidemiology Urine |
| title | Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T18%3A08%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20Serum%20Testosterone%20Levels%20Are%20Associated%20with%20Elevated%20Urinary%20Mandelic%20Acid,%20and%20Strontium%20Levels%20in%20Adult%20Men%20According%20to%20the%20US%202011-2012%20National%20Health%20and%20Nutrition%20Examination%20Survey&rft.jtitle=PloS%20one&rft.au=Xu,%20Cheng&rft.date=2015-05-21&rft.volume=10&rft.issue=5&rft.spage=e0127451&rft.epage=e0127451&rft.pages=e0127451-e0127451&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0127451&rft_dat=%3Cgale_plos_%3EA432309089%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1682424934&rft_id=info:pmid/25996772&rft_galeid=A432309089&rft_doaj_id=oai_doaj_org_article_3e7b3555ecec4ea9bc6922169f96b13c&rfr_iscdi=true |