Microbiome profiles in periodontitis in relation to host and disease characteristics
Periodontitis is an inflammatory condition that affects the supporting tissues surrounding teeth. The occurrence of periodontitis is associated with shifts in the structure of the communities that inhabit the gingival sulcus. Although great inter-subject variability in the subgingival microbiome has...
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| description | Periodontitis is an inflammatory condition that affects the supporting tissues surrounding teeth. The occurrence of periodontitis is associated with shifts in the structure of the communities that inhabit the gingival sulcus. Although great inter-subject variability in the subgingival microbiome has been observed in subjects with periodontitis, it is unclear whether distinct community types exist and if differences in microbial signatures correlate with host characteristics or with the variable clinical presentations of periodontitis. Therefore, in this study we explored the existence of different community types in periodontitis and their relationship with host demographic, medical and disease-related clinical characteristics. Clustering analyses of microbial abundance profiles suggested two types of communities (A and B) existed in the 34 subjects with periodontitis evaluated. Type B communities harbored greater proportions of certain periodontitis-associated taxa, including species historically associated with the disease, such as Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola, and taxa recently linked to periodontitis. In contrast, subjects with type A communities had increased proportions of different periodontitis-associated species, and were also enriched for health-associated species and core taxa (those equally prevalent in health and periodontitis). Periodontitis subgingival clusters were not associated with demographic, medical or disease-specific clinical parameters other than periodontitis extent (proportion of sites affected), which positively correlated with the total proportion of cluster B signature taxa. In conclusion, two types of microbial communities were detected in subjects with periodontitis. Host demographics and underlying medical conditions did not correlate with these profiles, which instead appeared to be related to periodontitis extent, with type B communities present in more widespread disease cases. The two identified periodontitis profiles may represent distinct dysbiotic processes potentially requiring community-tailored therapeutic interventions. |
| doi_str_mv | 10.1371/journal.pone.0127077 |
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The occurrence of periodontitis is associated with shifts in the structure of the communities that inhabit the gingival sulcus. Although great inter-subject variability in the subgingival microbiome has been observed in subjects with periodontitis, it is unclear whether distinct community types exist and if differences in microbial signatures correlate with host characteristics or with the variable clinical presentations of periodontitis. Therefore, in this study we explored the existence of different community types in periodontitis and their relationship with host demographic, medical and disease-related clinical characteristics. Clustering analyses of microbial abundance profiles suggested two types of communities (A and B) existed in the 34 subjects with periodontitis evaluated. Type B communities harbored greater proportions of certain periodontitis-associated taxa, including species historically associated with the disease, such as Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola, and taxa recently linked to periodontitis. In contrast, subjects with type A communities had increased proportions of different periodontitis-associated species, and were also enriched for health-associated species and core taxa (those equally prevalent in health and periodontitis). Periodontitis subgingival clusters were not associated with demographic, medical or disease-specific clinical parameters other than periodontitis extent (proportion of sites affected), which positively correlated with the total proportion of cluster B signature taxa. In conclusion, two types of microbial communities were detected in subjects with periodontitis. Host demographics and underlying medical conditions did not correlate with these profiles, which instead appeared to be related to periodontitis extent, with type B communities present in more widespread disease cases. The two identified periodontitis profiles may represent distinct dysbiotic processes potentially requiring community-tailored therapeutic interventions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0127077</identifier><identifier>PMID: 25984952</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antibiotics ; Associated species ; Cluster Analysis ; Clustering ; Correlation ; Demographics ; Demography ; Deoxyribonucleic acid ; Diabetes ; DNA ; Female ; Gingiva - microbiology ; Gingiva - pathology ; Gum disease ; Historical account ; Host-Pathogen Interactions ; Humans ; Inflammation ; Kidney diseases ; Male ; Microbial activity ; Microbiology ; Microbiota ; Microorganisms ; Middle Aged ; Oral hygiene ; Periodontitis ; Periodontitis - microbiology ; Porphyromonas gingivalis ; Severity of Illness Index ; Species ; Statistics, Nonparametric ; Streptococcus ; Studies ; Taxa ; Teeth ; Therapeutic applications ; Tissues</subject><ispartof>PloS one, 2015-05, Vol.10 (5), p.e0127077-e0127077</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Hong et al 2015 Hong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-3f62104036ed20efcf96a3d406fd938b56e1006ec31087d2d8452ef9350d3883</citedby><cites>FETCH-LOGICAL-c758t-3f62104036ed20efcf96a3d406fd938b56e1006ec31087d2d8452ef9350d3883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436126/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436126/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25984952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yilmaz, Özlem</contributor><creatorcontrib>Hong, Bo-Young</creatorcontrib><creatorcontrib>Furtado Araujo, Michel V</creatorcontrib><creatorcontrib>Strausbaugh, Linda D</creatorcontrib><creatorcontrib>Terzi, Evimaria</creatorcontrib><creatorcontrib>Ioannidou, Effie</creatorcontrib><creatorcontrib>Diaz, Patricia I</creatorcontrib><title>Microbiome profiles in periodontitis in relation to host and disease characteristics</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Periodontitis is an inflammatory condition that affects the supporting tissues surrounding teeth. The occurrence of periodontitis is associated with shifts in the structure of the communities that inhabit the gingival sulcus. Although great inter-subject variability in the subgingival microbiome has been observed in subjects with periodontitis, it is unclear whether distinct community types exist and if differences in microbial signatures correlate with host characteristics or with the variable clinical presentations of periodontitis. Therefore, in this study we explored the existence of different community types in periodontitis and their relationship with host demographic, medical and disease-related clinical characteristics. Clustering analyses of microbial abundance profiles suggested two types of communities (A and B) existed in the 34 subjects with periodontitis evaluated. Type B communities harbored greater proportions of certain periodontitis-associated taxa, including species historically associated with the disease, such as Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola, and taxa recently linked to periodontitis. In contrast, subjects with type A communities had increased proportions of different periodontitis-associated species, and were also enriched for health-associated species and core taxa (those equally prevalent in health and periodontitis). Periodontitis subgingival clusters were not associated with demographic, medical or disease-specific clinical parameters other than periodontitis extent (proportion of sites affected), which positively correlated with the total proportion of cluster B signature taxa. In conclusion, two types of microbial communities were detected in subjects with periodontitis. Host demographics and underlying medical conditions did not correlate with these profiles, which instead appeared to be related to periodontitis extent, with type B communities present in more widespread disease cases. The two identified periodontitis profiles may represent distinct dysbiotic processes potentially requiring community-tailored therapeutic interventions.</description><subject>Analysis</subject><subject>Antibiotics</subject><subject>Associated species</subject><subject>Cluster Analysis</subject><subject>Clustering</subject><subject>Correlation</subject><subject>Demographics</subject><subject>Demography</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>DNA</subject><subject>Female</subject><subject>Gingiva - microbiology</subject><subject>Gingiva - pathology</subject><subject>Gum disease</subject><subject>Historical account</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Microbial activity</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Middle Aged</subject><subject>Oral hygiene</subject><subject>Periodontitis</subject><subject>Periodontitis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Bo-Young</au><au>Furtado Araujo, Michel V</au><au>Strausbaugh, Linda D</au><au>Terzi, Evimaria</au><au>Ioannidou, Effie</au><au>Diaz, Patricia I</au><au>Yilmaz, Özlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microbiome profiles in periodontitis in relation to host and disease characteristics</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-05-18</date><risdate>2015</risdate><volume>10</volume><issue>5</issue><spage>e0127077</spage><epage>e0127077</epage><pages>e0127077-e0127077</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Periodontitis is an inflammatory condition that affects the supporting tissues surrounding teeth. The occurrence of periodontitis is associated with shifts in the structure of the communities that inhabit the gingival sulcus. Although great inter-subject variability in the subgingival microbiome has been observed in subjects with periodontitis, it is unclear whether distinct community types exist and if differences in microbial signatures correlate with host characteristics or with the variable clinical presentations of periodontitis. Therefore, in this study we explored the existence of different community types in periodontitis and their relationship with host demographic, medical and disease-related clinical characteristics. Clustering analyses of microbial abundance profiles suggested two types of communities (A and B) existed in the 34 subjects with periodontitis evaluated. Type B communities harbored greater proportions of certain periodontitis-associated taxa, including species historically associated with the disease, such as Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola, and taxa recently linked to periodontitis. In contrast, subjects with type A communities had increased proportions of different periodontitis-associated species, and were also enriched for health-associated species and core taxa (those equally prevalent in health and periodontitis). Periodontitis subgingival clusters were not associated with demographic, medical or disease-specific clinical parameters other than periodontitis extent (proportion of sites affected), which positively correlated with the total proportion of cluster B signature taxa. In conclusion, two types of microbial communities were detected in subjects with periodontitis. Host demographics and underlying medical conditions did not correlate with these profiles, which instead appeared to be related to periodontitis extent, with type B communities present in more widespread disease cases. The two identified periodontitis profiles may represent distinct dysbiotic processes potentially requiring community-tailored therapeutic interventions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25984952</pmid><doi>10.1371/journal.pone.0127077</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Antibiotics Associated species Cluster Analysis Clustering Correlation Demographics Demography Deoxyribonucleic acid Diabetes DNA Female Gingiva - microbiology Gingiva - pathology Gum disease Historical account Host-Pathogen Interactions Humans Inflammation Kidney diseases Male Microbial activity Microbiology Microbiota Microorganisms Middle Aged Oral hygiene Periodontitis Periodontitis - microbiology Porphyromonas gingivalis Severity of Illness Index Species Statistics, Nonparametric Streptococcus Studies Taxa Teeth Therapeutic applications Tissues |
| title | Microbiome profiles in periodontitis in relation to host and disease characteristics |
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