Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil)
Observational studies have reported fairly consistent inverse associations between coffee consumption and risk of type 2 diabetes, but this association has been little investigated with regard to lesser degrees of hyperglycemia and other alterations in glucose homeostasis. Additionally, the associat...
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| creator | Yarmolinsky, James Mueller, Noel T Duncan, Bruce B Bisi Molina, Maria Del Carmen Goulart, Alessandra C Schmidt, Maria Inês |
| description | Observational studies have reported fairly consistent inverse associations between coffee consumption and risk of type 2 diabetes, but this association has been little investigated with regard to lesser degrees of hyperglycemia and other alterations in glucose homeostasis. Additionally, the association between coffee consumption and diabetes has been rarely investigated in South American populations. We examined the cross-sectional relationships of coffee intake with newly diagnosed diabetes and measures of glucose homeostasis, insulin sensitivity, and insulin secretion, in a large Brazilian cohort of middle-aged and elderly individuals.
We used baseline data from 12,586 participants of the Longitudinal Study of Adult Health (ELSA-Brasil). Logistic regression analyses were performed to examine associations between coffee consumption and newly diagnosed diabetes. Analysis of covariance was used to assess coffee intake in relation to two-hour glucose from an oral glucose tolerance test, fasting glucose, glycated hemoglobin, fasting and -2-hour postload insulin and measures of insulin sensitivity.
We found an inverse association between coffee consumption and newly diagnosed diabetes, after adjusting for multiple covariates [23% and 26% lower odds of diabetes for those consuming coffee 2-3 and >3 times per day, respectively, compared to those reporting never or almost never consuming coffee, (p = .02)]. An inverse association was also found for 2-hour postload glucose [Never/almost never: 7.57 mmol/L, ≤1 time/day: 7.48 mmol/L, 2-3 times/day: 7.22 mmol/L, >3 times/day: 7.12 mol/L, p3 times/day: 262.2 pmol/L, p = 0.0005) but not with fasting insulin concentrations (p = .58).
Our present study provides further evidence of a protective effect of coffee on risk of adult-onset diabetes. This effect appears to act primarily, if not exclusively, through postprandial, as opposed to fasting, glucose homeostasis. |
| doi_str_mv | 10.1371/journal.pone.0126469 |
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We used baseline data from 12,586 participants of the Longitudinal Study of Adult Health (ELSA-Brasil). Logistic regression analyses were performed to examine associations between coffee consumption and newly diagnosed diabetes. Analysis of covariance was used to assess coffee intake in relation to two-hour glucose from an oral glucose tolerance test, fasting glucose, glycated hemoglobin, fasting and -2-hour postload insulin and measures of insulin sensitivity.
We found an inverse association between coffee consumption and newly diagnosed diabetes, after adjusting for multiple covariates [23% and 26% lower odds of diabetes for those consuming coffee 2-3 and >3 times per day, respectively, compared to those reporting never or almost never consuming coffee, (p = .02)]. An inverse association was also found for 2-hour postload glucose [Never/almost never: 7.57 mmol/L, ≤1 time/day: 7.48 mmol/L, 2-3 times/day: 7.22 mmol/L, >3 times/day: 7.12 mol/L, p<0.0001] but not with fasting glucose concentrations (p = 0.07). Coffee was additionally associated with 2-hour postload insulin [Never/almost never: 287.2 pmol/L, ≤1 time/day: 280.1 pmol/L, 2-3 times/day: 275.3 pmol/L, >3 times/day: 262.2 pmol/L, p = 0.0005) but not with fasting insulin concentrations (p = .58).
Our present study provides further evidence of a protective effect of coffee on risk of adult-onset diabetes. This effect appears to act primarily, if not exclusively, through postprandial, as opposed to fasting, glucose homeostasis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0126469</identifier><identifier>PMID: 25978631</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Brazil - epidemiology ; Caffeine ; Care and treatment ; Coffee ; Consumption ; Correlation analysis ; Covariance ; Cross-Sectional Studies ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - prevention & control ; Epidemiology ; Exercise ; Fasting ; Female ; Geriatrics ; Glucose ; Glucose - metabolism ; Glucose tolerance ; Glucose Tolerance Test ; Glycated Hemoglobin A - analysis ; Health aspects ; Health risk assessment ; Health risks ; Hemoglobin ; Homeostasis ; Homeostasis - drug effects ; Humans ; Hyperglycemia ; Hyperglycemia - epidemiology ; Insulin ; Insulin - blood ; Insulin resistance ; Insulin secretion ; Laboratory testing ; Longitudinal Studies ; Male ; Middle Aged ; Older people ; Regression analysis ; Risk factors ; Secretion ; Sensitivity ; Studies ; Type 2 diabetes</subject><ispartof>PloS one, 2015-05, Vol.10 (5), p.e0126469-e0126469</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Yarmolinsky et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Yarmolinsky et al 2015 Yarmolinsky et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-142f0216d04a25572d92053a082b9655faac41fe008dc5bb3cbf0aa9f8970d7c3</citedby><cites>FETCH-LOGICAL-c758t-142f0216d04a25572d92053a082b9655faac41fe008dc5bb3cbf0aa9f8970d7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433107/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433107/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27902,27903,53768,53770,79345,79346</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25978631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bhattacharya, Sanjoy</contributor><creatorcontrib>Yarmolinsky, James</creatorcontrib><creatorcontrib>Mueller, Noel T</creatorcontrib><creatorcontrib>Duncan, Bruce B</creatorcontrib><creatorcontrib>Bisi Molina, Maria Del Carmen</creatorcontrib><creatorcontrib>Goulart, Alessandra C</creatorcontrib><creatorcontrib>Schmidt, Maria Inês</creatorcontrib><title>Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Observational studies have reported fairly consistent inverse associations between coffee consumption and risk of type 2 diabetes, but this association has been little investigated with regard to lesser degrees of hyperglycemia and other alterations in glucose homeostasis. Additionally, the association between coffee consumption and diabetes has been rarely investigated in South American populations. We examined the cross-sectional relationships of coffee intake with newly diagnosed diabetes and measures of glucose homeostasis, insulin sensitivity, and insulin secretion, in a large Brazilian cohort of middle-aged and elderly individuals.
We used baseline data from 12,586 participants of the Longitudinal Study of Adult Health (ELSA-Brasil). Logistic regression analyses were performed to examine associations between coffee consumption and newly diagnosed diabetes. Analysis of covariance was used to assess coffee intake in relation to two-hour glucose from an oral glucose tolerance test, fasting glucose, glycated hemoglobin, fasting and -2-hour postload insulin and measures of insulin sensitivity.
We found an inverse association between coffee consumption and newly diagnosed diabetes, after adjusting for multiple covariates [23% and 26% lower odds of diabetes for those consuming coffee 2-3 and >3 times per day, respectively, compared to those reporting never or almost never consuming coffee, (p = .02)]. An inverse association was also found for 2-hour postload glucose [Never/almost never: 7.57 mmol/L, ≤1 time/day: 7.48 mmol/L, 2-3 times/day: 7.22 mmol/L, >3 times/day: 7.12 mol/L, p<0.0001] but not with fasting glucose concentrations (p = 0.07). Coffee was additionally associated with 2-hour postload insulin [Never/almost never: 287.2 pmol/L, ≤1 time/day: 280.1 pmol/L, 2-3 times/day: 275.3 pmol/L, >3 times/day: 262.2 pmol/L, p = 0.0005) but not with fasting insulin concentrations (p = .58).
Our present study provides further evidence of a protective effect of coffee on risk of adult-onset diabetes. This effect appears to act primarily, if not exclusively, through postprandial, as opposed to fasting, glucose homeostasis.</description><subject>Adults</subject><subject>Brazil - epidemiology</subject><subject>Caffeine</subject><subject>Care and treatment</subject><subject>Coffee</subject><subject>Consumption</subject><subject>Correlation analysis</subject><subject>Covariance</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - prevention & control</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Fasting</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hemoglobin</subject><subject>Homeostasis</subject><subject>Homeostasis - drug effects</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - epidemiology</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Insulin secretion</subject><subject>Laboratory testing</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Secretion</subject><subject>Sensitivity</subject><subject>Studies</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk21v0zAQxyMEYmPwDRBYmoQ2aS22Y-eBF0ihjG1SxSQKvLUc59x6cuMSO0C_FJ8Rp-2mFe0FiuScfL_7n8--S5KXBI9JmpO3N67vWmnHK9fCGBOasax8lBySMqWjjOL08T37IHnm_Q3GPC2y7GlyQHmZF1lKDpM_E6c1AJq41vfLVTCuPUOf4Zddo49GzlvnoRmsGgL4MyTbBl2HBXSosgE6OfAemRZd2F5FFl26JTgfpDf-HarQpHPej2agBlBaVMVlHX3IaRRl0NS1cxP6xgzOWTTWg6dqehvQJUgbFujkfDqrRh-6KGlPnydPtLQeXuz-R8m3T-dfJ5ej6fXF1aSajlTOizAijGpMSdZgJinnOW1KGouXuKB1mXGupVSMaMC4aBSv61TVGktZ6qLMcZOr9Ch5vdVdWefF7qq9IFlBcMlxVkTiaks0Tt6IVWeWslsLJ43YbLhuLmQXjLIgcuCUq_hmhdJsyEELynNFgeUgS15Hrfe7bH29hEZBGzpp90T3Pa1ZiLn7KRhLU4LzKHCyE-jcjx58EEvjFVgrW3D95tyU4pwVw7mP_0Efrm5HzWUswLTaxbxqEBUVSynBjGESqfEDVPwaWBoV-1KbuL8XcLoXEJkAv8Nc9t6Lq9mX_2evv--zb-6xi03jeGf7TXvug2wLqqExO9B3l0ywGMbq9jbEMFZiN1Yx7NX9B7oLup2j9C-lNR0W</recordid><startdate>20150515</startdate><enddate>20150515</enddate><creator>Yarmolinsky, James</creator><creator>Mueller, Noel T</creator><creator>Duncan, Bruce B</creator><creator>Bisi Molina, Maria Del Carmen</creator><creator>Goulart, Alessandra C</creator><creator>Schmidt, Maria Inês</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150515</creationdate><title>Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil)</title><author>Yarmolinsky, James ; Mueller, Noel T ; Duncan, Bruce B ; Bisi Molina, Maria Del Carmen ; Goulart, Alessandra C ; Schmidt, Maria Inês</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-142f0216d04a25572d92053a082b9655faac41fe008dc5bb3cbf0aa9f8970d7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adults</topic><topic>Brazil - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yarmolinsky, James</au><au>Mueller, Noel T</au><au>Duncan, Bruce B</au><au>Bisi Molina, Maria Del Carmen</au><au>Goulart, Alessandra C</au><au>Schmidt, Maria Inês</au><au>Bhattacharya, Sanjoy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-05-15</date><risdate>2015</risdate><volume>10</volume><issue>5</issue><spage>e0126469</spage><epage>e0126469</epage><pages>e0126469-e0126469</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Observational studies have reported fairly consistent inverse associations between coffee consumption and risk of type 2 diabetes, but this association has been little investigated with regard to lesser degrees of hyperglycemia and other alterations in glucose homeostasis. Additionally, the association between coffee consumption and diabetes has been rarely investigated in South American populations. We examined the cross-sectional relationships of coffee intake with newly diagnosed diabetes and measures of glucose homeostasis, insulin sensitivity, and insulin secretion, in a large Brazilian cohort of middle-aged and elderly individuals.
We used baseline data from 12,586 participants of the Longitudinal Study of Adult Health (ELSA-Brasil). Logistic regression analyses were performed to examine associations between coffee consumption and newly diagnosed diabetes. Analysis of covariance was used to assess coffee intake in relation to two-hour glucose from an oral glucose tolerance test, fasting glucose, glycated hemoglobin, fasting and -2-hour postload insulin and measures of insulin sensitivity.
We found an inverse association between coffee consumption and newly diagnosed diabetes, after adjusting for multiple covariates [23% and 26% lower odds of diabetes for those consuming coffee 2-3 and >3 times per day, respectively, compared to those reporting never or almost never consuming coffee, (p = .02)]. An inverse association was also found for 2-hour postload glucose [Never/almost never: 7.57 mmol/L, ≤1 time/day: 7.48 mmol/L, 2-3 times/day: 7.22 mmol/L, >3 times/day: 7.12 mol/L, p<0.0001] but not with fasting glucose concentrations (p = 0.07). Coffee was additionally associated with 2-hour postload insulin [Never/almost never: 287.2 pmol/L, ≤1 time/day: 280.1 pmol/L, 2-3 times/day: 275.3 pmol/L, >3 times/day: 262.2 pmol/L, p = 0.0005) but not with fasting insulin concentrations (p = .58).
Our present study provides further evidence of a protective effect of coffee on risk of adult-onset diabetes. This effect appears to act primarily, if not exclusively, through postprandial, as opposed to fasting, glucose homeostasis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25978631</pmid><doi>10.1371/journal.pone.0126469</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1681095068 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Brazil - epidemiology Caffeine Care and treatment Coffee Consumption Correlation analysis Covariance Cross-Sectional Studies Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - prevention & control Epidemiology Exercise Fasting Female Geriatrics Glucose Glucose - metabolism Glucose tolerance Glucose Tolerance Test Glycated Hemoglobin A - analysis Health aspects Health risk assessment Health risks Hemoglobin Homeostasis Homeostasis - drug effects Humans Hyperglycemia Hyperglycemia - epidemiology Insulin Insulin - blood Insulin resistance Insulin secretion Laboratory testing Longitudinal Studies Male Middle Aged Older people Regression analysis Risk factors Secretion Sensitivity Studies Type 2 diabetes |
| title | Coffee Consumption, Newly Diagnosed Diabetes, and Other Alterations in Glucose Homeostasis: A Cross-Sectional Analysis of the Longitudinal Study of Adult Health (ELSA-Brasil) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T08%3A45%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Coffee%20Consumption,%20Newly%20Diagnosed%20Diabetes,%20and%20Other%20Alterations%20in%20Glucose%20Homeostasis:%20A%20Cross-Sectional%20Analysis%20of%20the%20Longitudinal%20Study%20of%20Adult%20Health%20(ELSA-Brasil)&rft.jtitle=PloS%20one&rft.au=Yarmolinsky,%20James&rft.date=2015-05-15&rft.volume=10&rft.issue=5&rft.spage=e0126469&rft.epage=e0126469&rft.pages=e0126469-e0126469&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0126469&rft_dat=%3Cgale_plos_%3EA432104401%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1681095068&rft_id=info:pmid/25978631&rft_galeid=A432104401&rft_doaj_id=oai_doaj_org_article_7e525c3718cf49f8928257c2e47ea95b&rfr_iscdi=true |