Premature expression of Foxp3 in double-negative thymocytes

Peripheral immune regulation depends on the generation of thymic-derived regulatory T (tTreg) cells to maintain self-tolerance and to counterbalance overshooting immune responses. The expression of the Treg lineage defining transcription factor Foxp3 in developing tTreg cells depends on TCR signalin...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0127038-e0127038
Hauptverfasser:	Barra, Melanie M, Richards, David M, Hofer, Ann-Cathrin, Delacher, Michael, Feuerer, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens Autoimmune diseases Cancer CD3 antigen CD4 antigen CD5 antigen CD8 antigen Flow Cytometry Forkhead Transcription Factors - metabolism Forkhead Transcription Factors - physiology Foxp3 protein Gene Expression - genetics Gene Expression - physiology Genetic engineering Hepatocyte Nuclear Factor 1-alpha - deficiency Hepatocyte Nuclear Factor 1-alpha - physiology Immune response Immunological tolerance Immunology Immunoregulation Laboratories Laboratory rats Lymphocytes Lymphocytes T Medical research Mice Mice, Inbred C57BL Polymerase Chain Reaction Receptors, Antigen, T-Cell - metabolism Risk factors Signaling Statistical analysis T cell receptors T cells T-cell receptor Thymocytes Thymocytes - metabolism Thymus Transcription factors
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