Decreased Expression of Innate Immunity-Related Genes in Peripheral Blood Mononuclear Cells from Patients with IgG4-Related Disease

IgG4-related disease (IgG4-RD) is a new clinical entity of unknown etiology characterized by elevated serum IgG4 and tissue infiltration by IgG4-positive plasma cells. Although aberrancies in acquired immune system functions, including increases in Th2 and Treg cytokines observed in patients with Ig...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126582-e0126582
Hauptverfasser:	Nakajima, Akio, Masaki, Yasufumi, Nakamura, Takuji, Kawanami, Takafumi, Ishigaki, Yasuhito, Takegami, Tsutomu, Kawano, Mitsuhiro, Yamada, Kazunori, Tsukamoto, Norifumi, Matsui, Shoko, Saeki, Takako, Okazaki, Kazuichi, Kamisawa, Terumi, Miyashita, Taiichiro, Yakushijin, Yoshihiro, Fujikawa, Keita, Yamamoto, Motohisa, Hamano, Hideaki, Origuchi, Tomoki, Hirata, Shintaro, Tsuboi, Hiroto, Sumida, Takayuki, Morimoto, Hisanori, Sato, Tomomi, Iwao, Haruka, Miki, Miyuki, Sakai, Tomoyuki, Fujita, Yoshimasa, Tanaka, Masao, Fukushima, Toshihiro, Okazaki, Toshiro, Umehara, Hisanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Abnormalities Adult Aged Aged, 80 and over Allergies alpha-Defensins - genetics alpha-Defensins - metabolism Asthma Autoimmune Diseases - immunology Autoimmune Diseases - pathology Blood Care and treatment Case-Control Studies Cell cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Charcot-Leyden crystal protein Control methods Cytokines Deoxyribonucleic acid Development and progression DNA DNA microarrays Down-Regulation Etiology Female Gastroenterology Gene expression Genes Genetic aspects Glycoproteins - genetics Glycoproteins - metabolism Hematology Hospitals Humans Hypersensitivity Immune system Immunity Immunity (Disease) Immunity, Innate - genetics Immunoglobulin G Immunoglobulin G - blood Immunologic deficiency syndromes Immunology Infiltration Inflammation Innate immunity Interleukin 8 Interleukin 8 receptors Internal medicine Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocytes T Lysophospholipase - genetics Lysophospholipase - metabolism Male Medical research Medicine Membrane proteins Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Neutrophils Oligonucleotide Array Sequence Analysis Pancreatitis Pathogenesis Patients Peripheral blood mononuclear cells Plasma cells Polymerase chain reaction Proteins Real time Real-Time Polymerase Chain Reaction Receptors Receptors, Interleukin-8 - genetics Receptors, Interleukin-8 - metabolism Rheumatology Ribonucleic acid Risk factors RNA Steroids Th2 Cells - cytology Th2 Cells - immunology Therapy Up-Regulation
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