Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells

Induced pluripotent stem (iPS) cells have an enormous potential for physiological studies. A novel protocol was developed combining the derivation of iPS from peripheral blood with an optimized directed differentiation to cardiomyocytes and a subsequent metabolic selection. The human iPS cells were...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126596-e0126596
Hauptverfasser:	Fuerstenau-Sharp, Maya, Zimmermann, Martina E, Stark, Klaus, Jentsch, Nico, Klingenstein, Melanie, Drzymalski, Marzena, Wagner, Stefan, Maier, Lars S, Hehr, Ute, Baessler, Andrea, Fischer, Marcus, Hengstenberg, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Antibodies B cells Blood Calcium Signaling Calcium-binding protein Cardiomyocytes Cell culture Cell Differentiation Cells, Cultured Cellular Reprogramming Differentiation Drug discovery Drug testing Epidemiology Equipment costs Fibroblasts Flow Cytometry Gap Junctions Glucose Growth factors Heart Heart cells Heart diseases Hospitals Humans Immunomagnetic Separation Induced Pluripotent Stem Cells - physiology Internal medicine Karyotype Lactates Lactic acid Long QT syndrome Lymphocytes Lymphocytes T Myocytes, Cardiac - physiology Myosin Patch-Clamp Techniques Peripheral blood Pluripotency Preventive medicine Regenerative medicine Retroviridae - genetics Stem cells T cells T-Lymphocytes - physiology Troponin Troponin T Ventricle α-Actinin
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