TGF-Beta Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells

Transforming growth factor beta (TGF-β) is a multi-functional growth factor expressed in many tissues and organs. Genetic animal models have revealed the critical functions of TGF-β in craniofacial development, including the teeth and periodontal tissue. However, the physiological function of TGF-β...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125590-e0125590
Hauptverfasser:	Kawahara, Takanobu, Yamashita, Motozo, Ikegami, Kuniko, Nakamura, Tomomi, Yanagita, Manabu, Yamada, Satoru, Kitamura, Masahiro, Murakami, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Animal models Animals Benzamides - pharmacology Biocompatibility Biomedical materials Bone growth Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - physiology Bone morphogenetic proteins Calcification Cell culture Cell Differentiation Cell Line Cell Proliferation Collagen Craniofacial growth Cytokines Dentistry Dioxoles - pharmacology Drug Evaluation, Preclinical Enzyme inhibitors Extracellular matrix Fibroblasts Forming Gene expression Genetic aspects Growth factors Growth rate Humans Kinases Ligaments Mice, Inbred BALB C Negative feedback Organs Ossification Osteoblastogenesis Osteoblasts Periodontal ligament Periodontal Ligament - cytology Physiological aspects Polymerase chain reaction Proteins Reverse transcription Signal transduction Signaling Stem cells Teeth Tissues Transforming Growth Factor beta - physiology Transforming growth factor-a Transforming growth factor-b Transforming growth factors
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