A novel quantitative hemolytic assay coupled with restriction fragment length polymorphisms analysis enabled early diagnosis of atypical hemolytic uremic syndrome and identified unique predisposing mutations in Japan

For thrombotic microangiopathies (TMAs), the diagnosis of atypical hemolytic uremic syndrome (aHUS) is made by ruling out Shiga toxin-producing Escherichia coli (STEC)-associated HUS and ADAMTS13 activity-deficient thrombotic thrombocytopenic purpura (TTP), often using the exclusion criteria for sec...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0124655-e0124655
Hauptverfasser:	Yoshida, Yoko, Miyata, Toshiyuki, Matsumoto, Masanori, Shirotani-Ikejima, Hiroko, Uchida, Yumiko, Ohyama, Yoshifumi, Kokubo, Tetsuro, Fujimura, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animals Antibodies, Monoclonal - metabolism Asian Continental Ancestry Group - genetics Assaying Atypical Hemolytic Uremic Syndrome - diagnosis Atypical Hemolytic Uremic Syndrome - genetics Atypical Hemolytic Uremic Syndrome - immunology Bioassay Blood cells Blood transfusions Cellular biology Complement Complement activation Complement C3 - genetics Complement component C3 Complement factor H Complement Factor H - genetics Complement Factor H - metabolism Complement Hemolytic Activity Assay - methods Complement system Diagnosis E coli Early Diagnosis Erythrocytes Erythrocytes - immunology Female Gene mutation Genetic abnormalities Genetic aspects Genetic Predisposition to Disease Hemolysis Hemolytic uremic syndrome Humans Identification and classification Infections Japan Kinases Laboratories Life sciences Male Medical diagnosis Methods Monoclonal antibodies Mutation Ovis aries Pathogenesis Patients Pediatrics Plasma Polymorphism Polymorphism, Restriction Fragment Length Proteins Purpura Restriction fragment length polymorphism Restriction fragment length polymorphism analysis Sheep Sheep - blood Sheep - immunology Sheep red blood cells Shiga toxin Thrombocytopenic purpura Thrombotic thrombocytopenic purpura Toxins Transplants & implants
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