Comparison of genetic and epigenetic alterations of primary tumors and matched plasma samples in patients with colorectal cancer

Although recent advances in circulating DNA analysis allow the prediction of tumor genomes by noninvasive means, some challenges remain, which limit the widespread introduction of cfDNA in cancer diagnostics. We analyzed the status of the two best characterized colorectal cancer (CRC) genetic and ep...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126417-e0126417
Hauptverfasser:	Danese, Elisa, Minicozzi, Anna Maria, Benati, Marco, Montagnana, Martina, Paviati, Elisa, Salvagno, Gian Luca, Lima-Oliveira, Gabriel, Gusella, Milena, Pasini, Felice, Lippi, Giuseppe, Guidi, Gian Cesare
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Aged Biochemistry Biomarkers Blood plasma Cancer Cancer therapies Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Deoxyribonucleic acid Development and progression DNA DNA methylation DNA Methylation - genetics DNA Mutational Analysis DNA, Neoplasm - genetics Epigenesis, Genetic - genetics Epigenetics Evolution Female Gene expression Gene mutation Genetic aspects Genomes Health aspects Hospitals Humans Identification and classification K-Ras protein Laboratories Load matching Male Males Metastasis Mutation Patients Plasma Point Mutation - genetics Polymerase chain reaction Promoter Regions, Genetic Proto-Oncogene Proteins p21(ras) - genetics Septins - genetics Tissue analysis Tissues Tumors
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