Quantitative Analysis of the Enhanced Permeation and Retention (EPR) Effect

Tumor vasculature is characterized by a variety of abnormalities including irregular architecture, poor lymphatic drainage, and the upregulation of factors that increase the paracellular permeability. The increased permeability is important in mediating the uptake of an intravenously administered dr...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0123461-e0123461
Hauptverfasser:	Wong, Andrew D, Ye, Mao, Ulmschneider, Martin B, Searson, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Animal models Cancer therapies Clinical trials Dimensional analysis Dose-Response Relationship, Drug Doxorubicin Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Delivery Systems Extracellular matrix Extravasation Genetic aspects Humans Hypoxia Kinetics Lung cancer Lymphatic drainage Materials science Medical research Models, Theoretical Nanoparticles Neoplasms - metabolism Oncology Penetration Permeability Pharmacokinetics Pharmacology Polyethylene Glycols - administration & dosage Polyethylene Glycols - pharmacokinetics Polyethylene Glycols - pharmacology Quantitative analysis Retention Retention (Memory) Side effects Smooth muscle Solid tumors Tumor Microenvironment - drug effects Tumors
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