The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors

The murine Cebpa gene contains an evolutionarily conserved 453 bp enhancer located at +37 kb that, together with its promoter, directs expression to myeloid progenitors and to long-term hematopoietic stem cells in transgenic mice. In human acute myeloid leukemia cases, the enhancer lacks point mutat...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126385-e0126385
Hauptverfasser:	Cooper, Stacy, Guo, Hong, Friedman, Alan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Animals c-Myb protein CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-alpha - metabolism CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism CCAAT/enhancer-binding protein CEBPA gene Cell Line Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism CRISPR Deoxyribonucleic acid DNA Enhancer Elements, Genetic - genetics Ets-1 protein FLI-1 protein GATA2 Transcription Factor - genetics GATA2 Transcription Factor - metabolism Gene expression Genetic engineering Genetic transformation Genomes Granulocyte colony-stimulating factor Granulocytes Hematopoiesis Hematopoietic stem cells Humans Integrity Interleukin 3 Leukemia Leukocytes (granulocytic) Mice Monocytes Mutation Myeloid cells Myeloid leukemia Oncology Pediatrics Point Mutation - genetics Protein Binding Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism PU.1 protein Regulatory Sequences, Nucleic Acid - genetics Rodents Runx1 protein Stem cell transplantation Stem cells Trans-Activators - genetics Trans-Activators - metabolism Transcription Transcription factors Transformation Transgenic mice
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