CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation

The enzyme CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis. Here, we show that under homeostatic conditions CD38 is highly expressed on immune cells...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0126007-e0126007
Hauptverfasser:	Schneider, Michael, Schumacher, Valéa, Lischke, Timo, Lücke, Karsten, Meyer-Schwesinger, Catherine, Velden, Joachim, Koch-Nolte, Friedrich, Mittrücker, Hans-Willi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adenosine diphosphate ADP-ribosyl Cyclase 1 - genetics ADP-ribosyl Cyclase 1 - metabolism Analysis Animals Antigens Calcium CD38 antigen Cell activation Chemokines Chemotaxis Colitis Colitis - chemically induced Colitis - metabolism Colon Colon - cytology Colon - metabolism Cytokines Dendritic cells Dextran Dextran sulfate Dextran Sulfate - toxicity Disease Models, Animal Gene expression Immune system Immunology Inflammation Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestine Intestines - cytology Intestines - metabolism Leukocytes (granulocytic) Leukocytes - cytology Leukocytes - metabolism Lymphocytes Macrophages Medical treatment Metabolites Mice Mice, Inbred C57BL Mice, Knockout Mucosa Myeloid cells Neutrophils Physiological aspects Proteins Risk factors Rodents Sodium Sulfates
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