The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1

Clp chaperone-proteases are cylindrical complexes built from ATP-dependent chaperonerings that stack onto a proteolytic ClpP double-ring core to carry out substrate protein degradation.Interaction of the ClpP particle with the chaperone is mediated by an N-terminal loop and a hydrophobic surface pat...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125345-e0125345
Hauptverfasser:	Leodolter, Julia, Warweg, Jannis, Weber-Ban, Eilika
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinobacteria Adenosine triphosphatase Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Amino Acid Sequence Antibiotics ATPases ATPases Associated with Diverse Cellular Activities Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Binding Sites Biodegradation Bioinformatics Biophysics Chaperones Cloning Cloning, Molecular Defects Degradation E coli Endopeptidase Clp - chemistry Endopeptidase Clp - genetics Endopeptidase Clp - metabolism Escherichia coli - chemistry Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Gene Expression Regulation, Bacterial Heat-Shock Proteins - chemistry Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hydrophobicity Isoenzymes - chemistry Isoenzymes - genetics Isoenzymes - metabolism Models, Molecular Molecular biology Molecular Chaperones - chemistry Molecular Chaperones - genetics Molecular Chaperones - metabolism Molecular Sequence Data Mycobacterium tuberculosis Mycobacterium tuberculosis - chemistry Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Peptides Protease Proteases Protein Binding Protein Interaction Domains and Motifs Protein Structure, Secondary Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Proteinase Proteins Proteolysis Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Substrates Tuberculosis
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