The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2)

Cell number in the mouse thymus increases steadily during the first two weeks after birth. It then plateaus and begins to decline by seven weeks after birth. The factors governing these dramatic changes in cell production are not well understood. The data herein correlate levels of High mobility gro...

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Veröffentlicht in:	PloS one 2015-05, Vol.10 (5), p.e0125414-e0125414
Hauptverfasser:	Berent-Maoz, Beata, Montecino-Rodriguez, Encarnacion, Fice, Michael, Casero, David, Seet, Christopher S, Crooks, Gay M, Lowry, William, Dorshkind, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - immunology Aging - metabolism Animal care Animals Animals, Newborn Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Bioinformatics Birth Cell Differentiation Cell number Cell Proliferation Childbirth & labor Chromosomal proteins Embryo, Mammalian Embryonic Stem Cells - cytology Embryonic Stem Cells - immunology Embryonic Stem Cells - metabolism Fetal Stem Cells - cytology Fetal Stem Cells - immunology Fetal Stem Cells - metabolism Fetus Fetuses Gene expression Gene Expression Regulation, Developmental Hematology High mobility group proteins HMGA2 Protein - genetics HMGA2 Protein - immunology HMGA2 Protein - metabolism Humans Laboratory animals Lymphocytes Lymphocytes T Medicine Mice Mice, Inbred C57BL Mobility Neonates Newborn babies Newborn infants Organogenesis - genetics Organogenesis - immunology Pathology Plateaus Rodents Stem cells T cell receptors T cells T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymocytes - cytology Thymocytes - immunology Thymocytes - metabolism Thymopoiesis Thymus Thymus Gland - cytology Thymus Gland - embryology Thymus Gland - metabolism Young adults
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