The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Glucagon-like peptide-1 (GLP-1) is a metabolic hormone that is secreted in a glucose-dependent manner and enhances insulin secretion. GLP-1 receptors are also found in the brain where their signalling affects neuronal activity. We have previously shown that the GLP-1 receptor agonists, GLP-1 and exe...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0124765-e0124765
Hauptverfasser:	Korol, Sergiy V, Jin, Zhe, Birnir, Bryndis
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Brain CA3 Region, Hippocampal - cytology CA3 Region, Hippocampal - drug effects Cognition Diabetes Diazepam - pharmacology Electrophysiology Ethics GABA-A Receptor Agonists - pharmacology GLP-1 receptor agonists Hormones Insulin Insulin secretion Learning Ligands Memory Metabolism Neurons Neurons - drug effects Neurons - metabolism Neurosciences Patch-Clamp Techniques Peptides Peptides - pharmacology Pharmacology Rats Rats, Wistar Receptors Receptors, GABA-A - metabolism Software Statistical analysis Synaptic Potentials - drug effects Venoms - pharmacology
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