Dopaminergic lesions of the dorsolateral striatum in rats increase delay discounting in an impulsive choice task

Dysregulated dopamine transmission in striatal circuitry is associated with impulsivity. The current study evaluated the influence of dopaminergic inputs to the dorsolateral striatum on impulsive choice, one aspect of impulsive behavior. We implemented an operant task that measures impulsive choice...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0122063-e0122063
Hauptverfasser:	Tedford, Stephanie E, Persons, Amanda L, Napier, T Celeste
Format:	Artikel
Sprache:	eng
Schlagworte:	Addictions Addictive behaviors Animals Apathy Attention deficit hyperactivity disorder Behavior Behavior, Animal Choice Behavior Circuits Cocaine Corpus Striatum - physiopathology Decision making Delay time Dopamine Dopamine - metabolism Dopamine receptors Electric Stimulation Hypothalamus Hypothalamus (lateral) Hypothalamus - physiopathology Impulsive Behavior Impulsivity Intracranial self-stimulation Laboratory animals Lesions Male Metabolism Methamphetamine Neostriatum Operant conditioning Parkinson's disease Pharmacology Pressing Psychopharmacology Rats Rats, Sprague-Dawley Reinforcement Self Stimulation Substrates Synaptic Transmission
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