Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways
Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in...
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| creator | Liu, Yuping Zhu, Pingting Wang, Yingyu Wei, Zhonghong Tao, Li Zhu, Zhijie Sheng, Xiaobo Wang, Siliang Ruan, Junshan Liu, Zhaoguo Cao, Yuzhu Shan, Yunlong Sun, Lihua Wang, Aiyun Chen, Wenxing Lu, Yin |
| description | Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration and invasion in triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying the anticancer effects of DATS were further investigated.
MDA-MB-231 cells and HS 578t breast cancer cells were treated with different concentrations of DATS. DATS obviously suppressed the migration and invasion of two cell lines and changed the morphological. Moreover, DATS inhibited the mRNA/protein/ enzymes activities of MMP2/9 via attenuating the NF-κB pathway. DATS also inhibited ERK/MAPK rather than p38 and JNK.
DATS inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent. The inhibitory effects are associated with down-regulation of the transcriptional activities of NF-κB and ERK/MAPK signaling pathways. |
| doi_str_mv | 10.1371/journal.pone.0123781 |
| format | Article |
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MDA-MB-231 cells and HS 578t breast cancer cells were treated with different concentrations of DATS. DATS obviously suppressed the migration and invasion of two cell lines and changed the morphological. Moreover, DATS inhibited the mRNA/protein/ enzymes activities of MMP2/9 via attenuating the NF-κB pathway. DATS also inhibited ERK/MAPK rather than p38 and JNK.
DATS inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent. The inhibitory effects are associated with down-regulation of the transcriptional activities of NF-κB and ERK/MAPK signaling pathways.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0123781</identifier><identifier>PMID: 25927362</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Allium ; Allyl Compounds - chemistry ; Allyl Compounds - pharmacology ; Animals ; Anticancer properties ; Apoptosis ; Blockage ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer ; Cell adhesion & migration ; Cell cycle ; Cell Line, Tumor ; Cell Movement - drug effects ; Chinese medicine ; Collaboration ; Drug Screening Assays, Antitumor ; Extracellular matrix ; Female ; Garlic ; Humans ; JNK protein ; Kinases ; MAP Kinase Signaling System - drug effects ; Matrix Metalloproteinase 2 - biosynthesis ; Matrix Metalloproteinase 9 - biosynthesis ; Metastasis ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Proteins - metabolism ; NF-kappa B - metabolism ; Pharmacy ; Prevention ; Prostate cancer ; Proteins ; Signal transduction ; Signaling ; Sulfides - chemistry ; Sulfides - pharmacology ; Sulfur ; Tumors ; Zebrafish</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0123781-e0123781</ispartof><rights>2015 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Liu et al 2015 Liu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-77b7bccaf1143e667338844d5002f942d0e60fbce110789b61286d019446de93</citedby><cites>FETCH-LOGICAL-c526t-77b7bccaf1143e667338844d5002f942d0e60fbce110789b61286d019446de93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415928/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415928/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25927362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Paulmurugan, Ramasamy</contributor><creatorcontrib>Liu, Yuping</creatorcontrib><creatorcontrib>Zhu, Pingting</creatorcontrib><creatorcontrib>Wang, Yingyu</creatorcontrib><creatorcontrib>Wei, Zhonghong</creatorcontrib><creatorcontrib>Tao, Li</creatorcontrib><creatorcontrib>Zhu, Zhijie</creatorcontrib><creatorcontrib>Sheng, Xiaobo</creatorcontrib><creatorcontrib>Wang, Siliang</creatorcontrib><creatorcontrib>Ruan, Junshan</creatorcontrib><creatorcontrib>Liu, Zhaoguo</creatorcontrib><creatorcontrib>Cao, Yuzhu</creatorcontrib><creatorcontrib>Shan, Yunlong</creatorcontrib><creatorcontrib>Sun, Lihua</creatorcontrib><creatorcontrib>Wang, Aiyun</creatorcontrib><creatorcontrib>Chen, Wenxing</creatorcontrib><creatorcontrib>Lu, Yin</creatorcontrib><title>Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration and invasion in triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying the anticancer effects of DATS were further investigated.
MDA-MB-231 cells and HS 578t breast cancer cells were treated with different concentrations of DATS. DATS obviously suppressed the migration and invasion of two cell lines and changed the morphological. Moreover, DATS inhibited the mRNA/protein/ enzymes activities of MMP2/9 via attenuating the NF-κB pathway. DATS also inhibited ERK/MAPK rather than p38 and JNK.
DATS inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent. The inhibitory effects are associated with down-regulation of the transcriptional activities of NF-κB and ERK/MAPK signaling pathways.</description><subject>Allium</subject><subject>Allyl Compounds - chemistry</subject><subject>Allyl Compounds - pharmacology</subject><subject>Animals</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Blockage</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Chinese medicine</subject><subject>Collaboration</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Garlic</subject><subject>Humans</subject><subject>JNK protein</subject><subject>Kinases</subject><subject>MAP Kinase Signaling System - drug effects</subject><subject>Matrix Metalloproteinase 2 - biosynthesis</subject><subject>Matrix Metalloproteinase 9 - biosynthesis</subject><subject>Metastasis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Proteins - metabolism</subject><subject>NF-kappa B - metabolism</subject><subject>Pharmacy</subject><subject>Prevention</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Sulfides - chemistry</subject><subject>Sulfides - pharmacology</subject><subject>Sulfur</subject><subject>Tumors</subject><subject>Zebrafish</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUl1v0zAUjRCIjcI_QGCJl_HQ1o4TJ3mZ1JYNpq2lYn23bpKb1MWNg50U9Yfxwo_gN5Fs7bQhnmyde-65X8fz3jI6Yjxi441pbQV6VJsKR5T5PIrZM--UJdwfCp_y54_-J94r5zaUhjwW4qV34oeJH3Hhn3q_JlWjttiAa6BRGVmt0UKt0BFTkGaNZGn03rW6UDmSTwq03muysuoIQQmqck0P1RqHCyw7mR2SqcVOksygytCSs9ViOvtIdgrIbVvXFp1TVUnm86U_Tki6J1Ntsu89tLgc_vk9JVDl5OLb9Xg-WV6TW1V2g_bRJTTrn7B3r70XBWiHbw7vwFtdXqxmX4Y3Xz9fzSY3wyz0RTOMojRKswwKxgKOQkScx3EQ5CGlfpEEfk5R0CLNkDEaxUkqmB-LnLIkCESOCR947-9la22cPCzcSSaiiEciZD3j6p6RG9jI2qot2L00oOQdYGwpwXZ71SgZpIKyDHKWFQFNc0hZkIuCxgmGHIB3WueHam26xTzDqrGgn4g-jVRqLUuzk0HAunvGncDZQcCaHy26Rm6Vy1BrqNC0d33HUZDQ7vQD78M_1P9PF9yzMmucs1g8NMOo7E14zJK9CeXBhF3au8eDPCQdXcf_Akrh3Co</recordid><startdate>20150430</startdate><enddate>20150430</enddate><creator>Liu, Yuping</creator><creator>Zhu, Pingting</creator><creator>Wang, Yingyu</creator><creator>Wei, Zhonghong</creator><creator>Tao, Li</creator><creator>Zhu, Zhijie</creator><creator>Sheng, Xiaobo</creator><creator>Wang, Siliang</creator><creator>Ruan, Junshan</creator><creator>Liu, Zhaoguo</creator><creator>Cao, Yuzhu</creator><creator>Shan, Yunlong</creator><creator>Sun, Lihua</creator><creator>Wang, Aiyun</creator><creator>Chen, Wenxing</creator><creator>Lu, Yin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150430</creationdate><title>Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways</title><author>Liu, Yuping ; Zhu, Pingting ; Wang, Yingyu ; Wei, Zhonghong ; Tao, Li ; Zhu, Zhijie ; Sheng, Xiaobo ; Wang, Siliang ; Ruan, Junshan ; Liu, Zhaoguo ; Cao, Yuzhu ; Shan, Yunlong ; Sun, Lihua ; Wang, Aiyun ; Chen, Wenxing ; Lu, Yin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-77b7bccaf1143e667338844d5002f942d0e60fbce110789b61286d019446de93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Allium</topic><topic>Allyl Compounds - chemistry</topic><topic>Allyl Compounds - pharmacology</topic><topic>Animals</topic><topic>Anticancer properties</topic><topic>Apoptosis</topic><topic>Blockage</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Cell adhesion & migration</topic><topic>Cell cycle</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Chinese medicine</topic><topic>Collaboration</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Extracellular matrix</topic><topic>Female</topic><topic>Garlic</topic><topic>Humans</topic><topic>JNK protein</topic><topic>Kinases</topic><topic>MAP Kinase Signaling System - drug effects</topic><topic>Matrix Metalloproteinase 2 - biosynthesis</topic><topic>Matrix Metalloproteinase 9 - biosynthesis</topic><topic>Metastasis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Proteins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yuping</au><au>Zhu, Pingting</au><au>Wang, Yingyu</au><au>Wei, Zhonghong</au><au>Tao, Li</au><au>Zhu, Zhijie</au><au>Sheng, Xiaobo</au><au>Wang, Siliang</au><au>Ruan, Junshan</au><au>Liu, Zhaoguo</au><au>Cao, Yuzhu</au><au>Shan, Yunlong</au><au>Sun, Lihua</au><au>Wang, Aiyun</au><au>Chen, Wenxing</au><au>Lu, Yin</au><au>Paulmurugan, Ramasamy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-30</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0123781</spage><epage>e0123781</epage><pages>e0123781-e0123781</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Migration and invasion are two crucial steps of tumor metastasis. Blockage of these steps may be an effective strategy to reduce the risk. The objective of the present study was to investigate the effects of diallyl trisulfide (DATS), a natural organosulfuric compound with most sulfur atoms found in garlic, on migration and invasion in triple negative breast cancer (TNBC) cells. Molecular mechanisms underlying the anticancer effects of DATS were further investigated.
MDA-MB-231 cells and HS 578t breast cancer cells were treated with different concentrations of DATS. DATS obviously suppressed the migration and invasion of two cell lines and changed the morphological. Moreover, DATS inhibited the mRNA/protein/ enzymes activities of MMP2/9 via attenuating the NF-κB pathway. DATS also inhibited ERK/MAPK rather than p38 and JNK.
DATS inhibits MMP2/9 activity and the metastasis of TNBC cells, and emerges as a potential anti-cancer agent. The inhibitory effects are associated with down-regulation of the transcriptional activities of NF-κB and ERK/MAPK signaling pathways.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25927362</pmid><doi>10.1371/journal.pone.0123781</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2015-04, Vol.10 (4), p.e0123781-e0123781 |
| issn | 1932-6203 1932-6203 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Allium Allyl Compounds - chemistry Allyl Compounds - pharmacology Animals Anticancer properties Apoptosis Blockage Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell adhesion & migration Cell cycle Cell Line, Tumor Cell Movement - drug effects Chinese medicine Collaboration Drug Screening Assays, Antitumor Extracellular matrix Female Garlic Humans JNK protein Kinases MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 9 - biosynthesis Metastasis Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Proteins - metabolism NF-kappa B - metabolism Pharmacy Prevention Prostate cancer Proteins Signal transduction Signaling Sulfides - chemistry Sulfides - pharmacology Sulfur Tumors Zebrafish |
| title | Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T17%3A49%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antimetastatic%20Therapies%20of%20the%20Polysulfide%20Diallyl%20Trisulfide%20against%20Triple-Negative%20Breast%20Cancer%20(TNBC)%20via%20Suppressing%20MMP2/9%20by%20Blocking%20NF-%CE%BAB%20and%20ERK/MAPK%20Signaling%20Pathways&rft.jtitle=PloS%20one&rft.au=Liu,%20Yuping&rft.date=2015-04-30&rft.volume=10&rft.issue=4&rft.spage=e0123781&rft.epage=e0123781&rft.pages=e0123781-e0123781&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0123781&rft_dat=%3Cproquest_plos_%3E3671058591%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1677376519&rft_id=info:pmid/25927362&rft_doaj_id=oai_doaj_org_article_1ab601cad1cf40bdab14d6f089e53aa3&rfr_iscdi=true |