A Novel Function of CD82/KAI1 in Sialyl Lewis Antigen-Mediated Adhesion of Cancer Cells: Evidence for an Anti-Metastasis Effect by Down-Regulation of Sialyl Lewis Antigens

We have recently elucidated a novel function for CD82 in E-cadherin-mediated homocellular adhesion; due to this function, it can inhibit cancer cell dissociation from the primary cancer nest and limit metastasis. However, the effect of CD82 on selectin ligand-mediated heterocellular adhesion has not...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0124743-e0124743
Hauptverfasser:	Yoshihama, Naoya, Yamaguchi, Koujiro, Chigita, Satomi, Mine, Mariko, Abe, Masakazu, Ishii, Kotaro, Kobayashi, Yosuke, Akimoto, Naonari, Mori, Yoshihide, Sugiura, Tsuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Antibodies Antibodies - immunology Antigens Blood Blood vessels Cancer Cell Adhesion Cell Line, Tumor Cell Movement Dissociation DNA microarrays Down-Regulation E-cadherin Endothelium Epithelial cells Female Human Umbilical Vein Endothelial Cells Humans Inhibition Kangai-1 Protein - genetics Kangai-1 Protein - metabolism Lewis antigen Lewis antigens Lewis X Antigen - genetics Lewis X Antigen - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Lungs Metastases Mice Mice, Inbred BALB C Mice, Nude Oligonucleotide Array Sequence Analysis Overexpression Pretreatment Real-Time Polymerase Chain Reaction RNA, Messenger - metabolism RNA, Small Interfering - metabolism Sialyl Lewis a antigen Sialyl Lewis x antigen Sialyltransferases - antagonists & inhibitors Sialyltransferases - genetics Sialyltransferases - metabolism Transplantation, Heterologous Umbilical vein Western blotting
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