Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis

Prostaglandin (PG) E2 exhibits an anti-fibrotic effect in the lung in response to inflammatory reactions and is a high-affinity substrate of PG transporter (SLCO2A1). The present study aimed to evaluate the pathophysiological relevance of SLCO2A1 to bleomycin (BLM)-induced pulmonary fibrosis in mice...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0123895-e0123895
Hauptverfasser:	Nakanishi, Takeo, Hasegawa, Yoshitaka, Mimura, Reo, Wakayama, Tomohiko, Uetoko, Yuka, Komori, Hisakazu, Akanuma, Shin-Ichi, Hosoya, Ken-Ichi, Tamai, Ikumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animal models Animal tissues Animals Bleomycin Bronchoalveolar Lavage Fluid Bronchus Cell surface Cells, Cultured Collagen Connective tissues Dinoprostone - analysis Dinoprostone - immunology Epithelial cells Fibrosis Gene Deletion Gene Expression Regulation Immunohistochemistry Inflammation Lung - drug effects Lung - immunology Lung - pathology Lung diseases Male Mice Mice, Inbred C57BL Organic Anion Transporters - analysis Organic Anion Transporters - genetics Organic Anion Transporters - immunology Phosphates Prostaglandin E2 Protein kinase C Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - immunology Pulmonary Fibrosis - pathology Rats, Wistar Respiratory tract RNA, Messenger - genetics Signaling Smad3 protein Substrates Transcription Transforming growth factor-b1 Transporter
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