Restoring susceptibility induced MRI signal loss in rat brain at 9.4 T: A step towards whole brain functional connectivity imaging
The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture intr...
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| Veröffentlicht in: | PloS one 2015-04, Vol.10 (4), p.e0119450-e0119450 |
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| creator | Li, Rupeng Liu, Xiping Sidabras, Jason W Paulson, Eric S Jesmanowicz, Andrzej Nencka, Andrew S Hudetz, Anthony G Hyde, James S |
| description | The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible. |
| doi_str_mv | 10.1371/journal.pone.0119450 |
| format | Article |
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In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0119450</identifier><identifier>PMID: 25844644</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amygdala ; Analysis ; Animals ; Biophysics ; Brain ; Brain - diagnostic imaging ; Brain - physiology ; Brain Mapping - methods ; Brain Mapping - veterinary ; Brain research ; Cortex (insular) ; Ear, Middle - chemistry ; Echo-Planar Imaging - methods ; Echo-Planar Imaging - veterinary ; Fluorocarbons - administration & dosage ; Image Processing, Computer-Assisted - methods ; Laboratory animals ; Limbic system ; Liquid phases ; Magnetic fields ; Magnetic permeability ; Magnetic resonance imaging ; Magnetic susceptibility ; Medical imaging ; Medical research ; Middle ear ; Nervous system ; Neural networks ; Neuroimaging ; Perfluorocarbons ; Radiography ; Rats ; Seeds</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0119450-e0119450</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Li et al 2015 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4ddab6c50dca9ea9004ba757fa840268e06f447d95498c96a090bb4186e396183</citedby><cites>FETCH-LOGICAL-c692t-4ddab6c50dca9ea9004ba757fa840268e06f447d95498c96a090bb4186e396183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386820/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386820/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25844644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Zhang, Nanyin</contributor><creatorcontrib>Li, Rupeng</creatorcontrib><creatorcontrib>Liu, Xiping</creatorcontrib><creatorcontrib>Sidabras, Jason W</creatorcontrib><creatorcontrib>Paulson, Eric S</creatorcontrib><creatorcontrib>Jesmanowicz, Andrzej</creatorcontrib><creatorcontrib>Nencka, Andrew S</creatorcontrib><creatorcontrib>Hudetz, Anthony G</creatorcontrib><creatorcontrib>Hyde, James S</creatorcontrib><title>Restoring susceptibility induced MRI signal loss in rat brain at 9.4 T: A step towards whole brain functional connectivity imaging</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible.</description><subject>Amygdala</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biophysics</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiology</subject><subject>Brain Mapping - methods</subject><subject>Brain Mapping - veterinary</subject><subject>Brain research</subject><subject>Cortex (insular)</subject><subject>Ear, Middle - chemistry</subject><subject>Echo-Planar Imaging - methods</subject><subject>Echo-Planar Imaging - veterinary</subject><subject>Fluorocarbons - administration & dosage</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Laboratory animals</subject><subject>Limbic system</subject><subject>Liquid phases</subject><subject>Magnetic fields</subject><subject>Magnetic permeability</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic susceptibility</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Middle ear</subject><subject>Nervous system</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Perfluorocarbons</subject><subject>Radiography</subject><subject>Rats</subject><subject>Seeds</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99v0zAQxyMEYqPwHyCwhITgocVOHMfmAama-FFpaFIZvFqO46Su0riznY298pdzbbOpQXtAecjl8rk73319SfKS4BnJCvJh7XrfqXa2dZ2ZYUIEzfGj5JSILJ2yFGePj-yT5FkIa4zzjDP2NDlJc04po_Q0-bM0ITpvuwaFPmizjba0rY23yHZVr02Fvi8XKNgGSqHWhQB-5FVEpVdggSFmFF1-RHMUotmi6G6UrwK6WbnWDFDddzpat8ugXdcZ-LjeV9ioBgo_T57Uqg3mxfCeJD-_fL48-zY9v_i6OJufTzUTaZzSqlIl0zmutBJGCYxpqYq8qBWnOGXcYFZTWlQip4JrwRQWuCwp4cxkghGeTZLXh7xb6EMO4wuSsIJlGSuoAGJxICqn1nLr4YD-Vjpl5d7hfCOVj1a3RmLDKUvzvKY5o9rkCpNUQGlV1lVeYgW5Pg3V-nJjKm266FU7Sjr-09mVbNy1pKARB80mybshgXdXPagkNxYEalvVGdfvz01SggVjgL75B324u4FqFDRgu9pBXb1LKuc0FZwUhBOgZg9Q8FRmY0E-U1vwjwLejwKAieZ3bFQfglz8WP4_e_FrzL49YldGtXEVXNvvblIYg_QAag_305v6fsgEy92q3E1D7lZFDqsCYa-OBboPutuN7C97lg5i</recordid><startdate>20150406</startdate><enddate>20150406</enddate><creator>Li, 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susceptibility induced MRI signal loss in rat brain at 9.4 T: A step towards whole brain functional connectivity imaging</title><author>Li, Rupeng ; Liu, Xiping ; Sidabras, Jason W ; Paulson, Eric S ; Jesmanowicz, Andrzej ; Nencka, Andrew S ; Hudetz, Anthony G ; Hyde, James S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4ddab6c50dca9ea9004ba757fa840268e06f447d95498c96a090bb4186e396183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Amygdala</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biophysics</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiology</topic><topic>Brain Mapping - methods</topic><topic>Brain Mapping - veterinary</topic><topic>Brain research</topic><topic>Cortex (insular)</topic><topic>Ear, Middle - chemistry</topic><topic>Echo-Planar Imaging - methods</topic><topic>Echo-Planar Imaging - veterinary</topic><topic>Fluorocarbons - administration & dosage</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Laboratory animals</topic><topic>Limbic system</topic><topic>Liquid phases</topic><topic>Magnetic fields</topic><topic>Magnetic permeability</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic susceptibility</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Middle ear</topic><topic>Nervous system</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>Perfluorocarbons</topic><topic>Radiography</topic><topic>Rats</topic><topic>Seeds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Rupeng</creatorcontrib><creatorcontrib>Liu, Xiping</creatorcontrib><creatorcontrib>Sidabras, Jason W</creatorcontrib><creatorcontrib>Paulson, Eric S</creatorcontrib><creatorcontrib>Jesmanowicz, Andrzej</creatorcontrib><creatorcontrib>Nencka, Andrew 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Jason W</au><au>Paulson, Eric S</au><au>Jesmanowicz, Andrzej</au><au>Nencka, Andrew S</au><au>Hudetz, Anthony G</au><au>Hyde, James S</au><au>Zhang, Nanyin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Restoring susceptibility induced MRI signal loss in rat brain at 9.4 T: A step towards whole brain functional connectivity imaging</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-06</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0119450</spage><epage>e0119450</epage><pages>e0119450-e0119450</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25844644</pmid><doi>10.1371/journal.pone.0119450</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Amygdala Analysis Animals Biophysics Brain Brain - diagnostic imaging Brain - physiology Brain Mapping - methods Brain Mapping - veterinary Brain research Cortex (insular) Ear, Middle - chemistry Echo-Planar Imaging - methods Echo-Planar Imaging - veterinary Fluorocarbons - administration & dosage Image Processing, Computer-Assisted - methods Laboratory animals Limbic system Liquid phases Magnetic fields Magnetic permeability Magnetic resonance imaging Magnetic susceptibility Medical imaging Medical research Middle ear Nervous system Neural networks Neuroimaging Perfluorocarbons Radiography Rats Seeds |
| title | Restoring susceptibility induced MRI signal loss in rat brain at 9.4 T: A step towards whole brain functional connectivity imaging |
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