A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk

We performed a genome-wide association (GWA) study in 434 sporadic Creutzfeldt-Jakob disease (sCJD) patients and 1939 controls from the United Kingdom, Germany and The Netherlands. The findings were replicated in an independent sample of 1109 sCJD and 2264 controls provided by a multinational consor...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0123654-e0123654
Hauptverfasser:	Sanchez-Juan, Pascual, Bishop, Matthew T, Kovacs, Gabor G, Calero, Miguel, Aulchenko, Yurii S, Ladogana, Anna, Boyd, Alison, Lewis, Victoria, Ponto, Claudia, Calero, Olga, Poleggi, Anna, Carracedo, Ángel, van der Lee, Sven J, Ströbel, Thomas, Rivadeneira, Fernando, Hofman, Albert, Haïk, Stéphane, Combarros, Onofre, Berciano, José, Uitterlinden, Andre G, Collins, Steven J, Budka, Herbert, Brandel, Jean-Philippe, Laplanche, Jean Louis, Pocchiari, Maurizio, Zerr, Inga, Knight, Richard S G, Will, Robert G, van Duijn, Cornelia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino acids Biochemistry, Molecular Biology Bioinformatics Biology Bovine spongiform encephalopathy BSE Case-Control Studies Chronic illnesses Consortia Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - genetics Data processing Dementia Disease control Epidemiology Genes Genetic aspects Genome-wide association studies Genome-Wide Association Study - methods Genomes Genomics Genotypes Genotyping Germany Glutamate Glutamic acid receptors (metabotropic) Health risks Hospitals Humans Internal medicine Life Sciences Marking Medical research Meta-analysis Netherlands Neurology Neurosciences Pathogenesis Pathology Polymorphism, Single Nucleotide Prion protein Prion Proteins Prions (Proteins) Prions - genetics Proteins Receptors Receptors, Metabotropic Glutamate - genetics Risk factors Signal Transduction Single nucleotide polymorphisms Single-nucleotide polymorphism Surveillance Tagging Target recognition United Kingdom
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