Increased Short-Term Beat-To-Beat Variability of QT Interval in Patients with Acromegaly
Cardiovascular diseases, including ventricular arrhythmias are responsible for increased mortality in patients with acromegaly. Acromegaly may cause repolarization abnormalities such as QT prolongation and impairment of repolarization reserve enhancing liability to arrhythmia. The aim of this study...
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| creator | Orosz, Andrea Csajbók, Éva Czékus, Csilla Gavallér, Henriette Magony, Sándor Valkusz, Zsuzsanna Várkonyi, Tamás T Nemes, Attila Baczkó, István Forster, Tamás Wittmann, Tibor Papp, Julius Gy Varró, András Lengyel, Csaba |
| description | Cardiovascular diseases, including ventricular arrhythmias are responsible for increased mortality in patients with acromegaly. Acromegaly may cause repolarization abnormalities such as QT prolongation and impairment of repolarization reserve enhancing liability to arrhythmia. The aim of this study was to determine the short-term beat-to-beat QT variability in patients with acromegaly. Thirty acromegalic patients (23 women and 7 men, mean age±SD: 55.7±10.4 years) were compared with age- and sex-matched volunteers (mean age 51.3±7.6 years). Cardiac repolarization parameters including frequency corrected QT interval, PQ and QRS intervals, duration of terminal part of T waves (Tpeak-Tend) and short-term variability of QT interval were evaluated. All acromegalic patients and controls underwent transthoracic echocardiographic examination. Autonomic function was assessed by means of five standard cardiovascular reflex tests. Comparison of the two groups revealed no significant differences in the conventional ECG parameters of repolarization (QT: 401.1±30.6 ms vs 389.3±16.5 ms, corrected QT interval: 430.1±18.6 ms vs 425.6±17.3 ms, QT dispersion: 38.2±13.2 ms vs 36.6±10.2 ms; acromegaly vs control, respectively). However, short-term beat-to-beat QT variability was significantly increased in acromegalic patients (4.23±1.03 ms vs 3.02±0.80, P |
| doi_str_mv | 10.1371/journal.pone.0125639 |
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Acromegaly may cause repolarization abnormalities such as QT prolongation and impairment of repolarization reserve enhancing liability to arrhythmia. The aim of this study was to determine the short-term beat-to-beat QT variability in patients with acromegaly. Thirty acromegalic patients (23 women and 7 men, mean age±SD: 55.7±10.4 years) were compared with age- and sex-matched volunteers (mean age 51.3±7.6 years). Cardiac repolarization parameters including frequency corrected QT interval, PQ and QRS intervals, duration of terminal part of T waves (Tpeak-Tend) and short-term variability of QT interval were evaluated. All acromegalic patients and controls underwent transthoracic echocardiographic examination. Autonomic function was assessed by means of five standard cardiovascular reflex tests. Comparison of the two groups revealed no significant differences in the conventional ECG parameters of repolarization (QT: 401.1±30.6 ms vs 389.3±16.5 ms, corrected QT interval: 430.1±18.6 ms vs 425.6±17.3 ms, QT dispersion: 38.2±13.2 ms vs 36.6±10.2 ms; acromegaly vs control, respectively). However, short-term beat-to-beat QT variability was significantly increased in acromegalic patients (4.23±1.03 ms vs 3.02±0.80, P<0.0001). There were significant differences between the two groups in the echocardiographic dimensions (left ventricular end diastolic diameter: 52.6±5.4 mm vs 48.0±3.9 mm, left ventricular end systolic diameter: 32.3±5.2 mm vs 29.1±4.4 mm, interventricular septum: 11.1±2.2 mm vs 8.8±0.7 mm, posterior wall of left ventricle: 10.8±1.4 mm vs 8.9±0.7 mm, P<0.05, respectively). Short-term beat-to-beat QT variability was elevated in patients with acromegaly in spite of unchanged conventional parameters of ventricular repolarization. This enhanced temporal QT variability may be an early indicator of increased liability to arrhythmia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0125639</identifier><identifier>PMID: 25915951</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Acromegaly ; Acromegaly - complications ; Acromegaly - physiopathology ; Age ; Arrhythmia ; Arrhythmias, Cardiac - etiology ; Arrhythmias, Cardiac - physiopathology ; Autonomic nervous system ; Blood Pressure - physiology ; Cardiovascular diseases ; Case-Control Studies ; Comparative analysis ; Echocardiography ; EKG ; Electrocardiography ; Female ; Heart ; Heart - physiopathology ; Heart diseases ; Heart Rate - physiology ; Humans ; Legal liability ; Liability ; Male ; Middle Aged ; Patients ; Prolongation ; Septum ; Valsalva Maneuver - physiology ; Variability ; Ventricle</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0125639-e0125639</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Orosz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Orosz et al 2015 Orosz et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fc7bac16d66a07bc6d5f55a902db67cb3eaf1404bb78a95ed5f9ab8248659e253</citedby><cites>FETCH-LOGICAL-c692t-fc7bac16d66a07bc6d5f55a902db67cb3eaf1404bb78a95ed5f9ab8248659e253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411033/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411033/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25915951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orosz, Andrea</creatorcontrib><creatorcontrib>Csajbók, Éva</creatorcontrib><creatorcontrib>Czékus, Csilla</creatorcontrib><creatorcontrib>Gavallér, Henriette</creatorcontrib><creatorcontrib>Magony, Sándor</creatorcontrib><creatorcontrib>Valkusz, Zsuzsanna</creatorcontrib><creatorcontrib>Várkonyi, Tamás T</creatorcontrib><creatorcontrib>Nemes, Attila</creatorcontrib><creatorcontrib>Baczkó, István</creatorcontrib><creatorcontrib>Forster, Tamás</creatorcontrib><creatorcontrib>Wittmann, Tibor</creatorcontrib><creatorcontrib>Papp, Julius Gy</creatorcontrib><creatorcontrib>Varró, András</creatorcontrib><creatorcontrib>Lengyel, Csaba</creatorcontrib><title>Increased Short-Term Beat-To-Beat Variability of QT Interval in Patients with Acromegaly</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Cardiovascular diseases, including ventricular arrhythmias are responsible for increased mortality in patients with acromegaly. Acromegaly may cause repolarization abnormalities such as QT prolongation and impairment of repolarization reserve enhancing liability to arrhythmia. The aim of this study was to determine the short-term beat-to-beat QT variability in patients with acromegaly. Thirty acromegalic patients (23 women and 7 men, mean age±SD: 55.7±10.4 years) were compared with age- and sex-matched volunteers (mean age 51.3±7.6 years). Cardiac repolarization parameters including frequency corrected QT interval, PQ and QRS intervals, duration of terminal part of T waves (Tpeak-Tend) and short-term variability of QT interval were evaluated. All acromegalic patients and controls underwent transthoracic echocardiographic examination. Autonomic function was assessed by means of five standard cardiovascular reflex tests. Comparison of the two groups revealed no significant differences in the conventional ECG parameters of repolarization (QT: 401.1±30.6 ms vs 389.3±16.5 ms, corrected QT interval: 430.1±18.6 ms vs 425.6±17.3 ms, QT dispersion: 38.2±13.2 ms vs 36.6±10.2 ms; acromegaly vs control, respectively). However, short-term beat-to-beat QT variability was significantly increased in acromegalic patients (4.23±1.03 ms vs 3.02±0.80, P<0.0001). There were significant differences between the two groups in the echocardiographic dimensions (left ventricular end diastolic diameter: 52.6±5.4 mm vs 48.0±3.9 mm, left ventricular end systolic diameter: 32.3±5.2 mm vs 29.1±4.4 mm, interventricular septum: 11.1±2.2 mm vs 8.8±0.7 mm, posterior wall of left ventricle: 10.8±1.4 mm vs 8.9±0.7 mm, P<0.05, respectively). Short-term beat-to-beat QT variability was elevated in patients with acromegaly in spite of unchanged conventional parameters of ventricular repolarization. This enhanced temporal QT variability may be an early indicator of increased liability to arrhythmia.</description><subject>Abnormalities</subject><subject>Acromegaly</subject><subject>Acromegaly - complications</subject><subject>Acromegaly - physiopathology</subject><subject>Age</subject><subject>Arrhythmia</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Autonomic nervous system</subject><subject>Blood Pressure - physiology</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Comparative analysis</subject><subject>Echocardiography</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart</subject><subject>Heart - physiopathology</subject><subject>Heart diseases</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Legal liability</subject><subject>Liability</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Prolongation</subject><subject>Septum</subject><subject>Valsalva Maneuver - 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complications</topic><topic>Acromegaly - physiopathology</topic><topic>Age</topic><topic>Arrhythmia</topic><topic>Arrhythmias, Cardiac - etiology</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Autonomic nervous system</topic><topic>Blood Pressure - physiology</topic><topic>Cardiovascular diseases</topic><topic>Case-Control Studies</topic><topic>Comparative analysis</topic><topic>Echocardiography</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart</topic><topic>Heart - physiopathology</topic><topic>Heart diseases</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Legal liability</topic><topic>Liability</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Prolongation</topic><topic>Septum</topic><topic>Valsalva Maneuver - physiology</topic><topic>Variability</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orosz, Andrea</creatorcontrib><creatorcontrib>Csajbók, Éva</creatorcontrib><creatorcontrib>Czékus, Csilla</creatorcontrib><creatorcontrib>Gavallér, Henriette</creatorcontrib><creatorcontrib>Magony, Sándor</creatorcontrib><creatorcontrib>Valkusz, Zsuzsanna</creatorcontrib><creatorcontrib>Várkonyi, Tamás T</creatorcontrib><creatorcontrib>Nemes, Attila</creatorcontrib><creatorcontrib>Baczkó, István</creatorcontrib><creatorcontrib>Forster, Tamás</creatorcontrib><creatorcontrib>Wittmann, Tibor</creatorcontrib><creatorcontrib>Papp, Julius Gy</creatorcontrib><creatorcontrib>Varró, András</creatorcontrib><creatorcontrib>Lengyel, Csaba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orosz, Andrea</au><au>Csajbók, Éva</au><au>Czékus, Csilla</au><au>Gavallér, Henriette</au><au>Magony, Sándor</au><au>Valkusz, Zsuzsanna</au><au>Várkonyi, Tamás T</au><au>Nemes, Attila</au><au>Baczkó, István</au><au>Forster, Tamás</au><au>Wittmann, Tibor</au><au>Papp, Julius Gy</au><au>Varró, András</au><au>Lengyel, Csaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased Short-Term Beat-To-Beat Variability of QT Interval in Patients with Acromegaly</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-27</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0125639</spage><epage>e0125639</epage><pages>e0125639-e0125639</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cardiovascular diseases, including ventricular arrhythmias are responsible for increased mortality in patients with acromegaly. Acromegaly may cause repolarization abnormalities such as QT prolongation and impairment of repolarization reserve enhancing liability to arrhythmia. The aim of this study was to determine the short-term beat-to-beat QT variability in patients with acromegaly. Thirty acromegalic patients (23 women and 7 men, mean age±SD: 55.7±10.4 years) were compared with age- and sex-matched volunteers (mean age 51.3±7.6 years). Cardiac repolarization parameters including frequency corrected QT interval, PQ and QRS intervals, duration of terminal part of T waves (Tpeak-Tend) and short-term variability of QT interval were evaluated. All acromegalic patients and controls underwent transthoracic echocardiographic examination. Autonomic function was assessed by means of five standard cardiovascular reflex tests. Comparison of the two groups revealed no significant differences in the conventional ECG parameters of repolarization (QT: 401.1±30.6 ms vs 389.3±16.5 ms, corrected QT interval: 430.1±18.6 ms vs 425.6±17.3 ms, QT dispersion: 38.2±13.2 ms vs 36.6±10.2 ms; acromegaly vs control, respectively). However, short-term beat-to-beat QT variability was significantly increased in acromegalic patients (4.23±1.03 ms vs 3.02±0.80, P<0.0001). There were significant differences between the two groups in the echocardiographic dimensions (left ventricular end diastolic diameter: 52.6±5.4 mm vs 48.0±3.9 mm, left ventricular end systolic diameter: 32.3±5.2 mm vs 29.1±4.4 mm, interventricular septum: 11.1±2.2 mm vs 8.8±0.7 mm, posterior wall of left ventricle: 10.8±1.4 mm vs 8.9±0.7 mm, P<0.05, respectively). Short-term beat-to-beat QT variability was elevated in patients with acromegaly in spite of unchanged conventional parameters of ventricular repolarization. This enhanced temporal QT variability may be an early indicator of increased liability to arrhythmia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25915951</pmid><doi>10.1371/journal.pone.0125639</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-04, Vol.10 (4), p.e0125639-e0125639 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1676152243 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abnormalities Acromegaly Acromegaly - complications Acromegaly - physiopathology Age Arrhythmia Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - physiopathology Autonomic nervous system Blood Pressure - physiology Cardiovascular diseases Case-Control Studies Comparative analysis Echocardiography EKG Electrocardiography Female Heart Heart - physiopathology Heart diseases Heart Rate - physiology Humans Legal liability Liability Male Middle Aged Patients Prolongation Septum Valsalva Maneuver - physiology Variability Ventricle |
| title | Increased Short-Term Beat-To-Beat Variability of QT Interval in Patients with Acromegaly |
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