Bmi1 essentially mediates podocalyxin-enhanced Cisplatin chemoresistance in oral tongue squamous cell carcinoma

Oral tongue squamous cell carcinoma (OTSCC) is one of the most common head and neck cancers. Innate or acquired resistance to cisplatin, a standard chemotherapy agent for OTSCC, is common in patients with OTSCC. Understanding the molecular basis for cisplatin chemoresistance in OTSCC cells may serve...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0123208-e0123208
Hauptverfasser:	Zhou, Yueying, Zhang, Leiyi, Pan, Hao, Wang, Baisheng, Yan, Fei, Fang, Xiaodan, Munnee, Krishna, Tang, Zhangui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Antineoplastic Agents - pharmacology Apoptosis Apoptosis - genetics Biotechnology Breast cancer Cancer therapies Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Cell Line, Tumor Chemoresistance Chemotherapy Cisplatin Cisplatin - pharmacology Drug Resistance, Neoplasm - genetics Enzyme inhibitors Focal adhesion kinase Focal Adhesion Kinase 1 - genetics Gene expression Gene Expression Regulation, Neoplastic - genetics Head Humans Inhibitors Kinases Maxillofacial surgery Medical prognosis Metastasis Molecular modelling mRNA stability Neck Polycomb Repressive Complex 1 - genetics Prostate cancer RNA, Messenger - genetics Sialoglycoproteins - genetics Squamous cell carcinoma Stability Surgery Target recognition Therapeutic applications Tongue Tongue Neoplasms - drug therapy Tongue Neoplasms - genetics Up-Regulation - genetics
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