Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress

Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human chemotherapy resistant pancreatic cancer. PA triggered apoptosis in gemcitabine-resistant pancreatic cancer cells PANC-1 and MIA PaCa-2. Compar...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0122270
Hauptverfasser:	Cheng, Shujie, Swanson, Kristen, Eliaz, Isaac, McClintick, Jeanette N, Sandusky, George E, Sliva, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Activation Animals Anticancer properties Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biocompatibility Cancer Cell Line, Tumor Chemotherapy Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm - drug effects Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism Female Gemcitabine Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Growth inhibition Heat shock Heat shock proteins HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Mice Mice, Nude Pancreas - drug effects Pancreas - metabolism Pancreas - pathology Pancreatic cancer Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Poria - chemistry Protein folding Proteins Regulatory Factor X Transcription Factors Signal Transduction Stress Stresses Taurochenodeoxycholic Acid - pharmacology Tauroursodeoxycholic acid Tissues Toxicity Transcription Factor CHOP - genetics Transcription Factor CHOP - metabolism Transcription Factors - genetics Transcription Factors - metabolism Triterpenes - isolation & purification Triterpenes - pharmacology Unfolded Protein Response - drug effects X-Box Binding Protein 1 Xenograft Model Antitumor Assays
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