Clostridium perfringens Alpha-Toxin Induces Gm1a Clustering and Trka Phosphorylation in the Host Cell Membrane

Clostridium perfringens alpha-toxin elicits various immune responses such as the release of cytokines, chemokines, and superoxide via the GM1a/TrkA complex. Alpha-toxin possesses phospholipase C (PLC) hydrolytic activity that contributes to signal transduction in the pathogenesis of gas gangrene. Li...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0120497-e0120497
Hauptverfasser:	Takagishi, Teruhisa, Oda, Masataka, Kabura, Michiko, Kurosawa, Mie, Tominaga, Kaori, Urano, Shiori, Ueda, Yoshibumi, Kobayashi, Keiko, Kobayashi, Toshihide, Sakurai, Jun, Terao, Yutaka, Nagahama, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Activation Annexin V Bacterial Toxins - metabolism Bacterial Toxins - pharmacology Biological Transport Calcium-Binding Proteins - metabolism Calcium-Binding Proteins - pharmacology Cell Line Cell Membrane - drug effects Cell Membrane - metabolism Cell membranes Cellular signal transduction Chemokines Clostridium perfringens Clustering Cytokines Diacylglycerol Diglycerides Diglycerides - metabolism Enzymatic activity Fluorescence Fluorescence microscopy G(M1) Ganglioside - metabolism Gangrene Gas gangrene Host-Pathogen Interactions Humans Hydrophobicity Immune response Inhibition Interleukin 8 Interleukin-8 - metabolism Lipid metabolism Lipids Metabolism Models, Biological Pathogenesis Phosphatidylserine Phospholipase Phospholipase C Phospholipase C gamma - genetics Phospholipase C gamma - metabolism Phosphorylation Phosphorylation - drug effects Protein kinase C Receptor, trkA - metabolism RNA Interference siRNA Superoxide Superoxides Translocation TrkA protein Type C Phospholipases - metabolism Type C Phospholipases - pharmacology Yellow fluorescent protein α-Toxin
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