Random mutagenesis identifies a C-terminal region of YopD important for Yersinia type III secretion function

A common virulence mechanism among bacterial pathogens is the use of specialized secretion systems that deliver virulence proteins through a translocation channel inserted in the host cell membrane. During Yersinia infection, the host recognizes the type III secretion system mounting a pro-inflammat...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0120471
Hauptverfasser:	Solomon, Rebecca, Zhang, Weibing, McCrann, Grace, Bliska, James B, Viboud, Gloria I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino acid sequence Amino Acid Substitution Amino acids Animals Bacterial Outer Membrane Proteins - chemistry Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacterial Outer Membrane Proteins - toxicity Calcium Calcium - metabolism Cell Line Cell Survival - drug effects Female Health aspects HeLa Cells Humans Immune system Infection Infections Infectious diseases Inflammation Inflammatory response Kinases Laboratories MAP kinase Medicine Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase Kinases - metabolism Mutants Mutation NF-kappa B - metabolism NF-κB protein Parkinson's disease Pore formation Protein Structure, Tertiary Proteins Pseudotuberculosis Random mutagenesis Residues Secretion Signal transduction Translocation Virulence Virulence (Microbiology) Virulence - physiology Yersinia Yersinia pestis Yersinia pseudotuberculosis Yersinia pseudotuberculosis - metabolism
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