Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures

Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear. To explore whether alpha-synuclein oligomerization was associated with the cleavage of alpha-synuc...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119205
Hauptverfasser:	Xu, Bin, Liu, Wei, Deng, Yu, Yang, Tian-Yao, Feng, Shu, Xu, Zhao-Fa
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Analysis Animals Apoptosis Biotechnology Brain Brain slice preparation Calcium (intracellular) Calpain Calpain - antagonists & inhibitors Calpain - genetics Calpain - metabolism Cell adhesion & migration Cell injury Cleavage Control Environmental health Fragments Gene Expression Hypotheses Inhibitors Injury prevention L-Lactate dehydrogenase Laboratory animals Lactate dehydrogenase Lactic acid Manganese Manganese - toxicity mRNA Neurodegeneration Neurotoxicity Oligomerization Oligopeptides - pharmacology Parkinson's disease Pathology Physiological aspects Physiology Protein Multimerization Proteins Proteolysis Public health Rats, Wistar Rodents Signal transduction Signaling Studies Synuclein Tissue Culture Techniques Toxicity
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