Secreted Metabolites of Bifidobacterium infantis and Lactobacillus acidophilus Protect Immature Human Enterocytes from IL-1β-Induced Inflammation: A Transcription Profiling Analysis

Combination regimens of Bifidobacterium infantis and Lactobacillus acidophilus have been demonstrated to prevent necrotizing enterocolitis (NEC) in clinical trials. However, the molecular mechanisms responsible for this protective effect are not well understood. Additionally, conditioned media from...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0124549-e0124549
Hauptverfasser:	Guo, Shuangshuang, Guo, Yuming, Ergun, Ayla, Lu, Lei, Walker, W Allan, Ganguli, Kriston
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animal sciences Apoptosis Apoptosis - drug effects Bacteria Bifidobacterium - metabolism Biology Birth weight Cell adhesion Cell Adhesion - drug effects Cell cycle Cell survival Cells, Cultured Clinical trials Conditioning Culture Media, Conditioned - pharmacology Enterocolitis Enterocytes Enterocytes - cytology Enterocytes - drug effects Enterocytes - metabolism Epithelial cells Extracellular matrix Extracellular Matrix - metabolism Fetuses Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Genes Hospitals Humans I-kappa B Proteins - metabolism Immune response Immune system Immunology Inflammation Interleukin 6 Interleukin 8 Interleukin-1beta - pharmacology Interleukin-6 - analysis Interleukin-6 - genetics Interleukin-8 - analysis Interleukin-8 - genetics Intestine Laboratories Lactobacillus Lactobacillus acidophilus Lactobacillus acidophilus - metabolism Medical research Metabolites Models, Biological Molecular modelling Necrotizing enterocolitis NF-KappaB Inhibitor alpha NF-κB protein Nutrition Probiotics Rodents Signal transduction Signaling Small intestine Stimulation Studies Transcription activation Transcription Factor RelA - metabolism Zoology
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