Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms
This study aims to investigate the association between body mass index (BMI) or intra-abdominal fat measured by computed tomography (CT) and bowel symptoms. A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed....
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| Veröffentlicht in: | PloS one 2015-04, Vol.10 (4), p.e0123993-e0123993 |
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| creator | Nagata, Naoyoshi Sakamoto, Kayo Arai, Tomohiro Niikura, Ryota Shimbo, Takuro Shinozaki, Masafumi Ihana, Noriko Sekine, Katsunori Okubo, Hidetaka Watanabe, Kazuhiro Sakurai, Toshiyuki Yokoi, Chizu Yanase, Mikio Akiyama, Junichi Uemura, Naomi Noda, Mitsuhiko |
| description | This study aims to investigate the association between body mass index (BMI) or intra-abdominal fat measured by computed tomography (CT) and bowel symptoms.
A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed. Six symptoms (constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) using a 7-point Likert scale were evaluated between baseline and second questionnaire for test-retest reliability. Associations between BMI, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and symptom score were analyzed by a rank-ordered logistic model, adjusting for age, sex, smoking, and alcohol consumption, hypertension, diabetes mellitus, and dyslipidemia.
Some bowel symptom scores were significantly (p |
| doi_str_mv | 10.1371/journal.pone.0123993 |
| format | Article |
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A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed. Six symptoms (constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) using a 7-point Likert scale were evaluated between baseline and second questionnaire for test-retest reliability. Associations between BMI, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and symptom score were analyzed by a rank-ordered logistic model, adjusting for age, sex, smoking, and alcohol consumption, hypertension, diabetes mellitus, and dyslipidemia.
Some bowel symptom scores were significantly (p<0.05) different between the age groups, sexes, smoking, and alcohol consumption. In multivariate analysis, constipation was associated with low BMI (p<0.01), low VAT area (p = 0.01), and low SAT area (p<0.01). Moreover, hard stools was associated with low BMI (p<0.01) and low SAT area (p<0.01). The remaining symptoms were not significantly associated with BMI or intra-abdominal fat. Test-retest reliability of bowel symptom scores with a mean duration of 7.5 months was good (mean kappa, 0.672).
Both low BMI and low abdominal fat accumulation appears to be useful indicators of increased risk for constipation and hard stools. The long-term test-retest reliability of symptom score suggests that bowel symptoms relevant to BMI or visceral fat remain consistent over several months.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0123993</identifier><identifier>PMID: 25906052</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdominal Fat - diagnostic imaging ; Activities of daily living ; Adipose tissue ; Adults ; Aged ; Alcoholic beverages ; Body mass ; Body Mass Index ; Body size ; CAT scans ; Colon ; Colonic Diseases - diagnostic imaging ; Colonic Diseases - physiopathology ; Colonoscopy ; Computation ; Computed tomography ; Constipation ; Cross-Sectional Studies ; Diabetes mellitus ; Diarrhea ; Dyslipidemia ; Female ; Humans ; Hypertension ; Intestine ; Male ; Middle Aged ; Multivariate analysis ; Prospective Studies ; Rectal Diseases - diagnostic imaging ; Rectal Diseases - physiopathology ; Reliability analysis ; Smoking ; Surveys and Questionnaires ; Tomography, X-Ray Computed</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0123993-e0123993</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Nagata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Nagata et al 2015 Nagata et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-a77cd720498329bfbcf3e3926c3ea519878dbcfe7277b2c03a14aea842f032c83</citedby><cites>FETCH-LOGICAL-c758t-a77cd720498329bfbcf3e3926c3ea519878dbcfe7277b2c03a14aea842f032c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408111/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408111/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25906052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Alemany, Marià</contributor><creatorcontrib>Nagata, Naoyoshi</creatorcontrib><creatorcontrib>Sakamoto, Kayo</creatorcontrib><creatorcontrib>Arai, Tomohiro</creatorcontrib><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Shimbo, Takuro</creatorcontrib><creatorcontrib>Shinozaki, Masafumi</creatorcontrib><creatorcontrib>Ihana, Noriko</creatorcontrib><creatorcontrib>Sekine, Katsunori</creatorcontrib><creatorcontrib>Okubo, Hidetaka</creatorcontrib><creatorcontrib>Watanabe, Kazuhiro</creatorcontrib><creatorcontrib>Sakurai, Toshiyuki</creatorcontrib><creatorcontrib>Yokoi, Chizu</creatorcontrib><creatorcontrib>Yanase, Mikio</creatorcontrib><creatorcontrib>Akiyama, Junichi</creatorcontrib><creatorcontrib>Uemura, Naomi</creatorcontrib><creatorcontrib>Noda, Mitsuhiko</creatorcontrib><title>Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aims to investigate the association between body mass index (BMI) or intra-abdominal fat measured by computed tomography (CT) and bowel symptoms.
A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed. Six symptoms (constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) using a 7-point Likert scale were evaluated between baseline and second questionnaire for test-retest reliability. Associations between BMI, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and symptom score were analyzed by a rank-ordered logistic model, adjusting for age, sex, smoking, and alcohol consumption, hypertension, diabetes mellitus, and dyslipidemia.
Some bowel symptom scores were significantly (p<0.05) different between the age groups, sexes, smoking, and alcohol consumption. In multivariate analysis, constipation was associated with low BMI (p<0.01), low VAT area (p = 0.01), and low SAT area (p<0.01). Moreover, hard stools was associated with low BMI (p<0.01) and low SAT area (p<0.01). The remaining symptoms were not significantly associated with BMI or intra-abdominal fat. Test-retest reliability of bowel symptom scores with a mean duration of 7.5 months was good (mean kappa, 0.672).
Both low BMI and low abdominal fat accumulation appears to be useful indicators of increased risk for constipation and hard stools. The long-term test-retest reliability of symptom score suggests that bowel symptoms relevant to BMI or visceral fat remain consistent over several months.</description><subject>Abdominal Fat - diagnostic imaging</subject><subject>Activities of daily living</subject><subject>Adipose tissue</subject><subject>Adults</subject><subject>Aged</subject><subject>Alcoholic beverages</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>CAT scans</subject><subject>Colon</subject><subject>Colonic Diseases - diagnostic imaging</subject><subject>Colonic Diseases - physiopathology</subject><subject>Colonoscopy</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Constipation</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>Diarrhea</subject><subject>Dyslipidemia</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Intestine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Prospective Studies</subject><subject>Rectal Diseases - diagnostic imaging</subject><subject>Rectal Diseases - physiopathology</subject><subject>Reliability analysis</subject><subject>Smoking</subject><subject>Surveys and Questionnaires</subject><subject>Tomography, X-Ray Computed</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tv1DAQxyMEoqXwDRBYQkJw2MWvxM4FqaoKrFSpEq-r5fix6yWJF9uB7rfHYdNqg3pAPng0_s1_PGNPUTxHcIkIQ--2fgi9bJc735slRJjUNXlQnKKa4EWFIXl4ZJ8UT2LcQlgSXlWPixNc1rCCJT4t_KW1RiXgLWi83oNOxghcr80NkL3OVgpyIRvtO5eTASsT6IyMQzAaNHugfLcbUraT7_w6yN1mD3wP0saA4OKPg-xv04K473aZiU-LR1a20Tyb9rPi24fLrxefFlfXH1cX51cLxUqeFpIxpRmGtOYE141tlCWG1LhSxMgS1ZxxnX2GYcYarCCRiEojOcUWEqw4OSteHnR3rY9i6lUUqGIlYojzkVgdCO3lVuyC62TYCy-d-OvwYS1kSE61RtB8HYIsLilqKFdEsgo1GGqleUNrSrLW-ynb0HRGKzO2rZ2Jzk96txFr_0tQCjlCKAu8mQSC_zmYmETnojJtK3vjh8O9OStJOeZ69Q96f3UTtZa5ANdbn_OqUVScU5wrYbyuMrW8h8pLm86p_LGsy_5ZwNtZQGaSuUlrOcQoVl8-_z97_X3Ovj5iN0a2aRN9OyTn-zgH6QFUwccYjL1rMoJinIvbbohxLsQ0FznsxfED3QXdDgL5AycoCGg</recordid><startdate>20150423</startdate><enddate>20150423</enddate><creator>Nagata, Naoyoshi</creator><creator>Sakamoto, Kayo</creator><creator>Arai, Tomohiro</creator><creator>Niikura, Ryota</creator><creator>Shimbo, Takuro</creator><creator>Shinozaki, Masafumi</creator><creator>Ihana, Noriko</creator><creator>Sekine, Katsunori</creator><creator>Okubo, Hidetaka</creator><creator>Watanabe, Kazuhiro</creator><creator>Sakurai, Toshiyuki</creator><creator>Yokoi, Chizu</creator><creator>Yanase, Mikio</creator><creator>Akiyama, Junichi</creator><creator>Uemura, Naomi</creator><creator>Noda, Mitsuhiko</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150423</creationdate><title>Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms</title><author>Nagata, Naoyoshi ; Sakamoto, Kayo ; Arai, Tomohiro ; Niikura, Ryota ; Shimbo, Takuro ; Shinozaki, Masafumi ; Ihana, Noriko ; Sekine, Katsunori ; Okubo, Hidetaka ; Watanabe, Kazuhiro ; Sakurai, Toshiyuki ; Yokoi, Chizu ; Yanase, Mikio ; Akiyama, Junichi ; Uemura, Naomi ; Noda, Mitsuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-a77cd720498329bfbcf3e3926c3ea519878dbcfe7277b2c03a14aea842f032c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abdominal Fat - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagata, Naoyoshi</au><au>Sakamoto, Kayo</au><au>Arai, Tomohiro</au><au>Niikura, Ryota</au><au>Shimbo, Takuro</au><au>Shinozaki, Masafumi</au><au>Ihana, Noriko</au><au>Sekine, Katsunori</au><au>Okubo, Hidetaka</au><au>Watanabe, Kazuhiro</au><au>Sakurai, Toshiyuki</au><au>Yokoi, Chizu</au><au>Yanase, Mikio</au><au>Akiyama, Junichi</au><au>Uemura, Naomi</au><au>Noda, Mitsuhiko</au><au>Alemany, Marià</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-23</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0123993</spage><epage>e0123993</epage><pages>e0123993-e0123993</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study aims to investigate the association between body mass index (BMI) or intra-abdominal fat measured by computed tomography (CT) and bowel symptoms.
A cohort of 958 Japanese adults who underwent colonoscopy and CT and completed questionnaires after excluding colorectal diseases was analyzed. Six symptoms (constipation, diarrhea, loose stools, hard stools, fecal urgency, and incomplete evacuation) using a 7-point Likert scale were evaluated between baseline and second questionnaire for test-retest reliability. Associations between BMI, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and symptom score were analyzed by a rank-ordered logistic model, adjusting for age, sex, smoking, and alcohol consumption, hypertension, diabetes mellitus, and dyslipidemia.
Some bowel symptom scores were significantly (p<0.05) different between the age groups, sexes, smoking, and alcohol consumption. In multivariate analysis, constipation was associated with low BMI (p<0.01), low VAT area (p = 0.01), and low SAT area (p<0.01). Moreover, hard stools was associated with low BMI (p<0.01) and low SAT area (p<0.01). The remaining symptoms were not significantly associated with BMI or intra-abdominal fat. Test-retest reliability of bowel symptom scores with a mean duration of 7.5 months was good (mean kappa, 0.672).
Both low BMI and low abdominal fat accumulation appears to be useful indicators of increased risk for constipation and hard stools. The long-term test-retest reliability of symptom score suggests that bowel symptoms relevant to BMI or visceral fat remain consistent over several months.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25906052</pmid><doi>10.1371/journal.pone.0123993</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1675171888 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abdominal Fat - diagnostic imaging Activities of daily living Adipose tissue Adults Aged Alcoholic beverages Body mass Body Mass Index Body size CAT scans Colon Colonic Diseases - diagnostic imaging Colonic Diseases - physiopathology Colonoscopy Computation Computed tomography Constipation Cross-Sectional Studies Diabetes mellitus Diarrhea Dyslipidemia Female Humans Hypertension Intestine Male Middle Aged Multivariate analysis Prospective Studies Rectal Diseases - diagnostic imaging Rectal Diseases - physiopathology Reliability analysis Smoking Surveys and Questionnaires Tomography, X-Ray Computed |
| title | Effect of body mass index and intra-abdominal fat measured by computed tomography on the risk of bowel symptoms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T12%3A43%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20body%20mass%20index%20and%20intra-abdominal%20fat%20measured%20by%20computed%20tomography%20on%20the%20risk%20of%20bowel%20symptoms&rft.jtitle=PloS%20one&rft.au=Nagata,%20Naoyoshi&rft.date=2015-04-23&rft.volume=10&rft.issue=4&rft.spage=e0123993&rft.epage=e0123993&rft.pages=e0123993-e0123993&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0123993&rft_dat=%3Cgale_plos_%3EA422547896%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1675171888&rft_id=info:pmid/25906052&rft_galeid=A422547896&rft_doaj_id=oai_doaj_org_article_4a7731f2541b48c3a761b20dcd8b4943&rfr_iscdi=true |