Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer

Cancer cachexia (CC) is linked to poor prognosis. Although the mechanisms promoting this condition are not known, several circulating proteins have been proposed to contribute. We analyzed the plasma proteome in cancer subjects in order to identify factors associated with cachexia. Plasma was obtain...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0123566-e0123566
Hauptverfasser:	Arner, Peter, Henjes, Frauke, Schwenk, Jochen M, Darmanis, Spyros, Dahlman, Ingrid, Iresjö, Britt-Marie, Naredi, Peter, Agustsson, Thorhallur, Lundholm, Kent, Nilsson, Peter, Rydén, Mikael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - mortality Adenocarcinoma - pathology adult Aged albumin Amino acids Analysis Antibodies Apolipoproteins Biomarkers Biomarkers, Tumor - blood Biotechnology blood analysis Cachexia Cachexia - blood Cachexia - mortality Cachexia - pathology Cancer cancer prognosis Carnosine carnosine dipeptidase 1 Catabolism clinical article cohort analysis Cohort Studies controlled study Design factors Diabetes digestive system cancer Dipeptidase Dipeptidases - blood Disease disease association enzyme blood level enzyme immunoassay Female Gallbladder diseases Gastrointestinal cancer Glioblastoma Health aspects Hospitals human Humans Immunoassay Insulin-like growth factor I Kirurgi Laboratories Male Malnutrition Medical diagnosis Medical prognosis Metastases Metastasis Middle Aged outcome assessment Ovarian cancer Oxidation Pancreas Pancreatic cancer Pancreatitis Patients Plasma levels Prognosis Prostate cancer Proteins Proteomics Quality of life Rodents Science Screening somatomedin C Stomach Neoplasms - blood Stomach Neoplasms - mortality Stomach Neoplasms - pathology Surgery Survival Analysis unclassified drug validation process Weight loss weight reduction
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