Sintered indium-tin oxide particles induce pro-inflammatory responses in vitro, in part through inflammasome activation

Indium-tin oxide (ITO) is used to make transparent conductive coatings for touch-screen and liquid crystal display electronics. As the demand for consumer electronics continues to increase, so does the concern for occupational exposures to particles containing these potentially toxic metal oxides. I...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0124368-e0124368
Hauptverfasser:	Badding, Melissa A, Schwegler-Berry, Diane, Park, Ju-Hyeong, Fix, Natalie R, Cummings, Kristin J, Leonard, Stephen S
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated sintering Alveoli Analysis Animal models Animals B cells Carbon Carrier Proteins - genetics Carrier Proteins - immunology Cell activation Cell death Cell Line Chemical Industry Cytokines Cytotoxicity Dust Dust particles E coli Electronics Endotoxins Endotoxins - pharmacology Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - immunology Escherichia coli - immunology Fibrosis Gene Expression Regulation Humans Indium Indium tin oxides Inflammasomes Inflammasomes - agonists Inflammasomes - genetics Inflammasomes - immunology Inflammation Interleukin 6 Interleukin 8 Interleukin-1beta Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-8 - genetics Interleukin-8 - immunology Laboratories Liquid crystal displays Lung diseases Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - immunology Mice Molecular modelling NF-kappa B - genetics NF-kappa B - immunology NF-κB protein NLR Family, Pyrin Domain-Containing 3 Protein Occupational Exposure Occupational health Occupational safety Oxides Particle Size Particulates Pathogenesis Phagocytosis Phagocytosis - drug effects Potassium Respiratory diseases Respiratory tract diseases Signal Transduction Sintering Studies Tin Tin Compounds - chemistry Tin Compounds - classification Tin Compounds - toxicity Tin oxide Touch screens Toxicity Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-α Ventilation Workers
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