Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation
The human Torque Teno virus (TTV) causes persistent viremia in most immunocompetent individuals. Elevated TTV levels are observed after solid organ transplantation and are related to the extent of immunosuppression especially during the phase of maintenance immunosuppression. However, the extent to...
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| description | The human Torque Teno virus (TTV) causes persistent viremia in most immunocompetent individuals. Elevated TTV levels are observed after solid organ transplantation and are related to the extent of immunosuppression especially during the phase of maintenance immunosuppression. However, the extent to which the TTV increase in the early phase post-transplantation is associated with the patient's immunosuppressive state is unclear.
In this study, we assessed the TTV increase dynamics in detail during the first three months after lung transplantation under a defined immunosuppressive regimen and in relation to the pre-transplant TTV level.
Forty-six lung transplant recipients (LTRs) were included in this prospective longitudinal study. All received alemtuzumab induction combined with tacrolimus and corticosteroids immunosuppressive therapy. Plasma TTV DNA was monitored before transplantation and regularly within the first three months post-transplantation (n = 320 samples; mean sampling interval: 12.2 days).
In 43/46 LTRs (93%), TTV DNA was detectable before transplantation (median 4.4 log10 copies/mL; range: 2.0-6.4). All 46 LTRs showed a TTV increase post-transplantation, which followed a sigmoidal-shaped curve before the median peak level of 9.4 log10 copies/mL (range: 7.6-10.7) was reached at a median of day 67 (range: 41-92). The individual TTV DNA doubling times (range: 1.4-20.1 days) significantly correlated with the pre-transplant TTV levels calculated over 30 or 60 days post-transplantation (r = 0.61, 0.54, respectively; both P < 0.001), but did not correlate with the mean tacrolimus blood levels. Pre-transplant TTV levels were not associated with time and level of the patients' post-transplant TTV peak load.
The TTV level may be used to mirror the state of immunosuppression only after the patients' initial peak TTV level is reached. |
| doi_str_mv | 10.1371/journal.pone.0122975 |
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In this study, we assessed the TTV increase dynamics in detail during the first three months after lung transplantation under a defined immunosuppressive regimen and in relation to the pre-transplant TTV level.
Forty-six lung transplant recipients (LTRs) were included in this prospective longitudinal study. All received alemtuzumab induction combined with tacrolimus and corticosteroids immunosuppressive therapy. Plasma TTV DNA was monitored before transplantation and regularly within the first three months post-transplantation (n = 320 samples; mean sampling interval: 12.2 days).
In 43/46 LTRs (93%), TTV DNA was detectable before transplantation (median 4.4 log10 copies/mL; range: 2.0-6.4). All 46 LTRs showed a TTV increase post-transplantation, which followed a sigmoidal-shaped curve before the median peak level of 9.4 log10 copies/mL (range: 7.6-10.7) was reached at a median of day 67 (range: 41-92). The individual TTV DNA doubling times (range: 1.4-20.1 days) significantly correlated with the pre-transplant TTV levels calculated over 30 or 60 days post-transplantation (r = 0.61, 0.54, respectively; both P < 0.001), but did not correlate with the mean tacrolimus blood levels. Pre-transplant TTV levels were not associated with time and level of the patients' post-transplant TTV peak load.
The TTV level may be used to mirror the state of immunosuppression only after the patients' initial peak TTV level is reached.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0122975</identifier><identifier>PMID: 25894323</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Correlation analysis ; Corticoids ; Corticosteroids ; Cytomegalovirus ; Deoxyribonucleic acid ; Disease ; DNA ; Drug dosages ; Female ; Humans ; Immunosuppression ; Immunosuppression - adverse effects ; Immunosuppressive agents ; Immunotherapy ; Kinetics ; Lung Transplantation - adverse effects ; Lungs ; Male ; Middle Aged ; Monoclonal antibodies ; Organ transplant recipients ; Organ transplantation ; Patients ; Peak load ; Plasma ; Plasma - drug effects ; Plasma - virology ; Tacrolimus ; Thoracic surgery ; Torque ; Torque teno virus - physiology ; Transplantation ; Transplants & implants ; Viral Load - drug effects ; Virology ; Virus diseases ; Viruses ; Young Adult</subject><ispartof>PloS one, 2015-04, Vol.10 (3), p.e0122975-e0122975</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Görzer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Görzer et al 2015 Görzer et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-cc1b661fe823105ce71d96d64c74c73274ce24d24d39f9960c5c92f7033f73023</citedby><cites>FETCH-LOGICAL-c692t-cc1b661fe823105ce71d96d64c74c73274ce24d24d39f9960c5c92f7033f73023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404260/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404260/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25894323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schildgen, Oliver</contributor><creatorcontrib>Görzer, Irene</creatorcontrib><creatorcontrib>Jaksch, Peter</creatorcontrib><creatorcontrib>Kundi, Michael</creatorcontrib><creatorcontrib>Seitz, Tamara</creatorcontrib><creatorcontrib>Klepetko, Walter</creatorcontrib><creatorcontrib>Puchhammer-Stöckl, Elisabeth</creatorcontrib><title>Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The human Torque Teno virus (TTV) causes persistent viremia in most immunocompetent individuals. Elevated TTV levels are observed after solid organ transplantation and are related to the extent of immunosuppression especially during the phase of maintenance immunosuppression. However, the extent to which the TTV increase in the early phase post-transplantation is associated with the patient's immunosuppressive state is unclear.
In this study, we assessed the TTV increase dynamics in detail during the first three months after lung transplantation under a defined immunosuppressive regimen and in relation to the pre-transplant TTV level.
Forty-six lung transplant recipients (LTRs) were included in this prospective longitudinal study. All received alemtuzumab induction combined with tacrolimus and corticosteroids immunosuppressive therapy. Plasma TTV DNA was monitored before transplantation and regularly within the first three months post-transplantation (n = 320 samples; mean sampling interval: 12.2 days).
In 43/46 LTRs (93%), TTV DNA was detectable before transplantation (median 4.4 log10 copies/mL; range: 2.0-6.4). All 46 LTRs showed a TTV increase post-transplantation, which followed a sigmoidal-shaped curve before the median peak level of 9.4 log10 copies/mL (range: 7.6-10.7) was reached at a median of day 67 (range: 41-92). The individual TTV DNA doubling times (range: 1.4-20.1 days) significantly correlated with the pre-transplant TTV levels calculated over 30 or 60 days post-transplantation (r = 0.61, 0.54, respectively; both P < 0.001), but did not correlate with the mean tacrolimus blood levels. Pre-transplant TTV levels were not associated with time and level of the patients' post-transplant TTV peak load.
The TTV level may be used to mirror the state of immunosuppression only after the patients' initial peak TTV level is reached.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Correlation analysis</subject><subject>Corticoids</subject><subject>Corticosteroids</subject><subject>Cytomegalovirus</subject><subject>Deoxyribonucleic acid</subject><subject>Disease</subject><subject>DNA</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Immunosuppression - adverse effects</subject><subject>Immunosuppressive agents</subject><subject>Immunotherapy</subject><subject>Kinetics</subject><subject>Lung Transplantation - adverse effects</subject><subject>Lungs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Organ transplant recipients</subject><subject>Organ transplantation</subject><subject>Patients</subject><subject>Peak load</subject><subject>Plasma</subject><subject>Plasma - drug effects</subject><subject>Plasma - virology</subject><subject>Tacrolimus</subject><subject>Thoracic surgery</subject><subject>Torque</subject><subject>Torque teno virus - physiology</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Viral Load - drug effects</subject><subject>Virology</subject><subject>Virus diseases</subject><subject>Viruses</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99rFDEQxxdRbK3-B6ILgujDnUkmm2xehFL8cVCo6OmbhGw2uUvZS67JbrH_vTlvW2-lD7IhCdnPfCczmSmK5xjNMXD87jIM0atuvg3ezBEmRPDqQXGMBZAZIwgeHuyPiicpXSJUQc3Y4-KIVLWgQOC4-PklmlkflU_bTvm-zHPaqHIZ4tVgyqXxobx2cUhlF1RbKt-WzutoVDJle-PVxulUKtubWHaDX5V_lVTvgn9aPLKqS-bZuJ4U3z9-WJ59np1ffFqcnZ7PNBOkn2mNG8awNTUBjCptOG4FaxnVPA8geTaEtnmAsEIwpCstiOUIwHJABE6Kl3vdbReSHDOTJGac0goLzjKx2BNtUJdyG91GxRsZlJN_DkJcSRV7pzsjrbYtQEMawTEFxAQCWreNxcAAdANZ6_3obWg2ptXG57C7iej0j3druQrXklJECUNZ4M0oEENOc-rlxiVtupw3E4b9vXOUnFYZffUPen90I7VSOQDnbch-9U5UnlICdVVzvHM7v4fKX2vyO-Yysi6fTwzeTgwy05tf_UoNKcnFt6__z178mLKvD9i1UV2_TqEbdiWTpiDdgzqGlKKxd0nGSO664DYbctcFcuyCbPbi8IHujG7LHn4DOs0BkQ</recordid><startdate>20150420</startdate><enddate>20150420</enddate><creator>Görzer, Irene</creator><creator>Jaksch, Peter</creator><creator>Kundi, Michael</creator><creator>Seitz, Tamara</creator><creator>Klepetko, Walter</creator><creator>Puchhammer-Stöckl, Elisabeth</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150420</creationdate><title>Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation</title><author>Görzer, Irene ; Jaksch, Peter ; Kundi, Michael ; Seitz, Tamara ; Klepetko, Walter ; Puchhammer-Stöckl, Elisabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-cc1b661fe823105ce71d96d64c74c73274ce24d24d39f9960c5c92f7033f73023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Correlation analysis</topic><topic>Corticoids</topic><topic>Corticosteroids</topic><topic>Cytomegalovirus</topic><topic>Deoxyribonucleic acid</topic><topic>Disease</topic><topic>DNA</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Humans</topic><topic>Immunosuppression</topic><topic>Immunosuppression - adverse effects</topic><topic>Immunosuppressive agents</topic><topic>Immunotherapy</topic><topic>Kinetics</topic><topic>Lung Transplantation - adverse effects</topic><topic>Lungs</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Organ transplant recipients</topic><topic>Organ transplantation</topic><topic>Patients</topic><topic>Peak load</topic><topic>Plasma</topic><topic>Plasma - drug effects</topic><topic>Plasma - virology</topic><topic>Tacrolimus</topic><topic>Thoracic surgery</topic><topic>Torque</topic><topic>Torque teno virus - physiology</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Viral Load - drug effects</topic><topic>Virology</topic><topic>Virus diseases</topic><topic>Viruses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Görzer, Irene</creatorcontrib><creatorcontrib>Jaksch, Peter</creatorcontrib><creatorcontrib>Kundi, Michael</creatorcontrib><creatorcontrib>Seitz, Tamara</creatorcontrib><creatorcontrib>Klepetko, Walter</creatorcontrib><creatorcontrib>Puchhammer-Stöckl, Elisabeth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Görzer, Irene</au><au>Jaksch, Peter</au><au>Kundi, Michael</au><au>Seitz, Tamara</au><au>Klepetko, Walter</au><au>Puchhammer-Stöckl, Elisabeth</au><au>Schildgen, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-20</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0122975</spage><epage>e0122975</epage><pages>e0122975-e0122975</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The human Torque Teno virus (TTV) causes persistent viremia in most immunocompetent individuals. Elevated TTV levels are observed after solid organ transplantation and are related to the extent of immunosuppression especially during the phase of maintenance immunosuppression. However, the extent to which the TTV increase in the early phase post-transplantation is associated with the patient's immunosuppressive state is unclear.
In this study, we assessed the TTV increase dynamics in detail during the first three months after lung transplantation under a defined immunosuppressive regimen and in relation to the pre-transplant TTV level.
Forty-six lung transplant recipients (LTRs) were included in this prospective longitudinal study. All received alemtuzumab induction combined with tacrolimus and corticosteroids immunosuppressive therapy. Plasma TTV DNA was monitored before transplantation and regularly within the first three months post-transplantation (n = 320 samples; mean sampling interval: 12.2 days).
In 43/46 LTRs (93%), TTV DNA was detectable before transplantation (median 4.4 log10 copies/mL; range: 2.0-6.4). All 46 LTRs showed a TTV increase post-transplantation, which followed a sigmoidal-shaped curve before the median peak level of 9.4 log10 copies/mL (range: 7.6-10.7) was reached at a median of day 67 (range: 41-92). The individual TTV DNA doubling times (range: 1.4-20.1 days) significantly correlated with the pre-transplant TTV levels calculated over 30 or 60 days post-transplantation (r = 0.61, 0.54, respectively; both P < 0.001), but did not correlate with the mean tacrolimus blood levels. Pre-transplant TTV levels were not associated with time and level of the patients' post-transplant TTV peak load.
The TTV level may be used to mirror the state of immunosuppression only after the patients' initial peak TTV level is reached.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25894323</pmid><doi>10.1371/journal.pone.0122975</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Correlation analysis Corticoids Corticosteroids Cytomegalovirus Deoxyribonucleic acid Disease DNA Drug dosages Female Humans Immunosuppression Immunosuppression - adverse effects Immunosuppressive agents Immunotherapy Kinetics Lung Transplantation - adverse effects Lungs Male Middle Aged Monoclonal antibodies Organ transplant recipients Organ transplantation Patients Peak load Plasma Plasma - drug effects Plasma - virology Tacrolimus Thoracic surgery Torque Torque teno virus - physiology Transplantation Transplants & implants Viral Load - drug effects Virology Virus diseases Viruses Young Adult |
| title | Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T04%3A40%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pre-transplant%20plasma%20Torque%20Teno%20virus%20load%20and%20increase%20dynamics%20after%20lung%20transplantation&rft.jtitle=PloS%20one&rft.au=G%C3%B6rzer,%20Irene&rft.date=2015-04-20&rft.volume=10&rft.issue=3&rft.spage=e0122975&rft.epage=e0122975&rft.pages=e0122975-e0122975&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0122975&rft_dat=%3Cgale_plos_%3EA423858710%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1674451976&rft_id=info:pmid/25894323&rft_galeid=A423858710&rft_doaj_id=oai_doaj_org_article_fcfd33b2b971430690348dbf13633cb3&rfr_iscdi=true |