Dynamic responses of selective brain white matter fiber tracts to binge alcohol and recovery in the rat
To determine the dynamics of white matter vulnerability to excessive alcohol consumption, diffusion tensor imaging (DTI) was used in an animal model of alcohol exposure. Quantitative, in vivo fiber tracking results are presented from rats with DTI conducted at 3 time points: baseline; after 4 days o...
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| Veröffentlicht in: | PloS one 2015-04, Vol.10 (4), p.e0124885 |
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| description | To determine the dynamics of white matter vulnerability to excessive alcohol consumption, diffusion tensor imaging (DTI) was used in an animal model of alcohol exposure. Quantitative, in vivo fiber tracking results are presented from rats with DTI conducted at 3 time points: baseline; after 4 days of intragastric alcohol to blood alcohol levels of ~250 mg/dL; and after one week of recovery. Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix. These effects were confirmed with tract-based spatial statistics (TBSS). The directionality of changes in DTI metrics reproduce those observed in human alcoholism. That a single exposure to binge alcohol can cause substantial transient changes detectable in DTI metrics demonstrates the potential for rapid neuroplasticity. |
| doi_str_mv | 10.1371/journal.pone.0124885 |
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Quantitative, in vivo fiber tracking results are presented from rats with DTI conducted at 3 time points: baseline; after 4 days of intragastric alcohol to blood alcohol levels of ~250 mg/dL; and after one week of recovery. Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix. These effects were confirmed with tract-based spatial statistics (TBSS). The directionality of changes in DTI metrics reproduce those observed in human alcoholism. That a single exposure to binge alcohol can cause substantial transient changes detectable in DTI metrics demonstrates the potential for rapid neuroplasticity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0124885</identifier><identifier>PMID: 25894968</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol use ; Alcoholic beverages ; Alcoholism ; Animal models ; Animals ; Anisotropy ; Binge Drinking - blood ; Binge Drinking - diagnosis ; Binge Drinking - pathology ; Brain ; Change detection ; Corpus callosum ; Diffusion Tensor Imaging ; Drinking (Alcoholic beverages) ; Drug abuse ; Ethanol - adverse effects ; Ethanol - blood ; Exposure ; Fornix ; Image Processing, Computer-Assisted ; Magnetic resonance imaging ; Male ; Neural plasticity ; Neuroimaging ; Rats ; Rats, Wistar ; Recovery ; Recovery (Medical) ; Rodents ; Studies ; Substantia alba ; Tensors ; Time Factors ; White Matter - drug effects ; White Matter - pathology</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0124885</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Pfefferbaum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Pfefferbaum et al 2015 Pfefferbaum et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-600ba02d5c28b30e0208fc39ef47d38543bb6dde2daaab3d65ebe0b54dc7f0e43</citedby><cites>FETCH-LOGICAL-c692t-600ba02d5c28b30e0208fc39ef47d38543bb6dde2daaab3d65ebe0b54dc7f0e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403879/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403879/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25894968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Gozzi, Alessandro</contributor><creatorcontrib>Pfefferbaum, Adolf</creatorcontrib><creatorcontrib>Zahr, Natalie M</creatorcontrib><creatorcontrib>Mayer, Dirk</creatorcontrib><creatorcontrib>Rohlfing, Torsten</creatorcontrib><creatorcontrib>Sullivan, Edith V</creatorcontrib><title>Dynamic responses of selective brain white matter fiber tracts to binge alcohol and recovery in the rat</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine the dynamics of white matter vulnerability to excessive alcohol consumption, diffusion tensor imaging (DTI) was used in an animal model of alcohol exposure. Quantitative, in vivo fiber tracking results are presented from rats with DTI conducted at 3 time points: baseline; after 4 days of intragastric alcohol to blood alcohol levels of ~250 mg/dL; and after one week of recovery. Binge alcohol followed by a week of sobriety resulted in rapidly reversible decreases in fractional anisotropy (FA), a measure of the coherence of fiber tracts, in callosal genu and fimbria-fornix but not splenium; and increases in mean diffusivity (MD), an index of freely diffusing water in tissue, selective to the fimbria-fornix. These effects were confirmed with tract-based spatial statistics (TBSS). The directionality of changes in DTI metrics reproduce those observed in human alcoholism. That a single exposure to binge alcohol can cause substantial transient changes detectable in DTI metrics demonstrates the potential for rapid neuroplasticity.</description><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcoholism</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anisotropy</subject><subject>Binge Drinking - blood</subject><subject>Binge Drinking - diagnosis</subject><subject>Binge Drinking - pathology</subject><subject>Brain</subject><subject>Change detection</subject><subject>Corpus callosum</subject><subject>Diffusion Tensor Imaging</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Drug abuse</subject><subject>Ethanol - adverse effects</subject><subject>Ethanol - blood</subject><subject>Exposure</subject><subject>Fornix</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Neural plasticity</subject><subject>Neuroimaging</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recovery</subject><subject>Recovery (Medical)</subject><subject>Rodents</subject><subject>Studies</subject><subject>Substantia alba</subject><subject>Tensors</subject><subject>Time Factors</subject><subject>White Matter - 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| subjects | Alcohol use Alcoholic beverages Alcoholism Animal models Animals Anisotropy Binge Drinking - blood Binge Drinking - diagnosis Binge Drinking - pathology Brain Change detection Corpus callosum Diffusion Tensor Imaging Drinking (Alcoholic beverages) Drug abuse Ethanol - adverse effects Ethanol - blood Exposure Fornix Image Processing, Computer-Assisted Magnetic resonance imaging Male Neural plasticity Neuroimaging Rats Rats, Wistar Recovery Recovery (Medical) Rodents Studies Substantia alba Tensors Time Factors White Matter - drug effects White Matter - pathology |
| title | Dynamic responses of selective brain white matter fiber tracts to binge alcohol and recovery in the rat |
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