Potentiating effect of UVA irradiation on anticancer activity of Carboplatin derivatives involving 7-azaindoles

The moderate-to-high in vitro cytotoxicity against ovarian A2780 (IC50 = 4.7-14.4 μM), prostate LNCaP (IC50 = 18.7-30.8 μM) and prostate PC-3 (IC50 = 17.6-42.3 μM) human cancer cell lines of the platinum(II) cyclobutane-1,1'-dicarboxylato complexes [Pt(cbdc)(naza)2] (1-6; cbdc = cyclobutane-1,1...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0123595
Hauptverfasser:	Vanco, Ján, Dvorák, ZdenÄk, Pracharová, Jitka, Kaspárková, Jana, Å tarha, Pavel, Radosová-Muchová, Tereza, Trávnícek, ZdenÄk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Anticancer properties Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Buthionine sulfoximine Buthionine Sulfoximine - pharmacology Cancer Cancer treatment Carboplatin Carboplatin - chemistry Carboplatin - pharmacology Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cell Survival - radiation effects Cisplatin Cyclobutane Cytotoxicity Deoxyribonucleic acid DNA DNA adducts DNA Adducts - chemistry DNA Adducts - genetics DNA Breaks, Double-Stranded - drug effects DNA Breaks, Double-Stranded - radiation effects Drug Synergism Glutathione Guanosine Humans Indoles - chemistry Indoles - pharmacology Irradiation Light irradiation Molecular Structure Neoplasms - genetics Neoplasms - pathology NMR Nuclear magnetic resonance Nucleic Acid Conformation Phototoxicity Platinum Prostate Proton Magnetic Resonance Spectroscopy Spectrometry, Mass, Electrospray Ionization Substitutes Toxicity Transcription Tumor cell lines Ultraviolet radiation Ultraviolet Rays Viability γ-Glutamylcysteine
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