Predictors of in vitro fertilization outcomes in women with highest follicle-stimulating hormone levels ≥ 12 IU/L: a prospective cohort study
The purpose of this study is to evaluate factors predictive of outcomes in women with highest follicle-stimulating hormone (FSH) levels ≥ 12 IU/L on basal testing, undergoing in vitro fertilization (IVF). A prospective cohort study was conducted at Stanford University Hospital in the Reproductive En...
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| Veröffentlicht in: | PloS one 2015-04, Vol.10 (4), p.e0124789-e0124789 |
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| creator | Huang, Lina N Jun, Sunny H Drubach, Nathalie Dahan, Michael H |
| description | The purpose of this study is to evaluate factors predictive of outcomes in women with highest follicle-stimulating hormone (FSH) levels ≥ 12 IU/L on basal testing, undergoing in vitro fertilization (IVF).
A prospective cohort study was conducted at Stanford University Hospital in the Reproductive Endocrinology and Infertility Center for 12 months. Women age 21 to 43 undergoing IVF with highest FSH levels on baseline testing were included. Donor/Recipient and frozen embryo cycles were excluded from this study. Prognostic factors evaluated in association with clinical pregnancy rates were type of infertility diagnosis and IVF stimulation parameters.
The current study found that factors associated with clinical pregnancy were: increased number of mature follicles on the day of triggering, number of oocytes retrieved, number of Metaphase II oocytes if intracytoplasmic sperm injection was done, and number of embryos developed 24 hours after retrieval.
Our findings suggest that it would be beneficial for women with increased FSH levels to attempt a cycle of IVF. Results of ovarian stimulation, especially embryo quantity appear to be the best predictors of IVF outcomes and those can only be obtained from a cycle of IVF. Therefore, increased basal FSH levels should not discourage women from attempting a cycle of IVF. |
| doi_str_mv | 10.1371/journal.pone.0124789 |
| format | Article |
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A prospective cohort study was conducted at Stanford University Hospital in the Reproductive Endocrinology and Infertility Center for 12 months. Women age 21 to 43 undergoing IVF with highest FSH levels on baseline testing were included. Donor/Recipient and frozen embryo cycles were excluded from this study. Prognostic factors evaluated in association with clinical pregnancy rates were type of infertility diagnosis and IVF stimulation parameters.
The current study found that factors associated with clinical pregnancy were: increased number of mature follicles on the day of triggering, number of oocytes retrieved, number of Metaphase II oocytes if intracytoplasmic sperm injection was done, and number of embryos developed 24 hours after retrieval.
Our findings suggest that it would be beneficial for women with increased FSH levels to attempt a cycle of IVF. Results of ovarian stimulation, especially embryo quantity appear to be the best predictors of IVF outcomes and those can only be obtained from a cycle of IVF. Therefore, increased basal FSH levels should not discourage women from attempting a cycle of IVF.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0124789</identifier><identifier>PMID: 25867175</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Cohort analysis ; Embryos ; Endocrinology ; Female ; Fertility clinics ; Fertilization ; Fertilization in Vitro ; Follicle Stimulating Hormone - blood ; Follicle-stimulating hormone ; Follicles ; Humans ; In vitro fertilization ; In vitro methods and tests ; Infertility ; Metaphase ; Oocytes ; Ovarian Reserve ; Pregnancy ; Pregnancy Rate ; Prospective Studies ; Stimulation ; Women</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0124789-e0124789</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Huang et al 2015 Huang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3c95856c0a07132ac21cd03f3eb8ded986b0955ef920addde01b081789256ca03</citedby><cites>FETCH-LOGICAL-c692t-3c95856c0a07132ac21cd03f3eb8ded986b0955ef920addde01b081789256ca03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395083/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395083/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25867175$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Lina N</creatorcontrib><creatorcontrib>Jun, Sunny H</creatorcontrib><creatorcontrib>Drubach, Nathalie</creatorcontrib><creatorcontrib>Dahan, Michael H</creatorcontrib><title>Predictors of in vitro fertilization outcomes in women with highest follicle-stimulating hormone levels ≥ 12 IU/L: a prospective cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The purpose of this study is to evaluate factors predictive of outcomes in women with highest follicle-stimulating hormone (FSH) levels ≥ 12 IU/L on basal testing, undergoing in vitro fertilization (IVF).
A prospective cohort study was conducted at Stanford University Hospital in the Reproductive Endocrinology and Infertility Center for 12 months. Women age 21 to 43 undergoing IVF with highest FSH levels on baseline testing were included. Donor/Recipient and frozen embryo cycles were excluded from this study. Prognostic factors evaluated in association with clinical pregnancy rates were type of infertility diagnosis and IVF stimulation parameters.
The current study found that factors associated with clinical pregnancy were: increased number of mature follicles on the day of triggering, number of oocytes retrieved, number of Metaphase II oocytes if intracytoplasmic sperm injection was done, and number of embryos developed 24 hours after retrieval.
Our findings suggest that it would be beneficial for women with increased FSH levels to attempt a cycle of IVF. Results of ovarian stimulation, especially embryo quantity appear to be the best predictors of IVF outcomes and those can only be obtained from a cycle of IVF. Therefore, increased basal FSH levels should not discourage women from attempting a cycle of IVF.</description><subject>Adult</subject><subject>Analysis</subject><subject>Cohort analysis</subject><subject>Embryos</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fertility clinics</subject><subject>Fertilization</subject><subject>Fertilization in Vitro</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle-stimulating hormone</subject><subject>Follicles</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>In vitro methods and tests</subject><subject>Infertility</subject><subject>Metaphase</subject><subject>Oocytes</subject><subject>Ovarian Reserve</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Prospective Studies</subject><subject>Stimulation</subject><subject>Women</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk92K1DAUx4so7rr6BqIBQfRiZvPRpK0XwrL4MTCwoq63IU3TNkvazCbp6PoGXvkUvphPYup0l6nshRTSkPzOP-f8k5MkjxFcIpKh4ws7uF6Y5cb2agkRTrO8uJMcooLgBcOQ3N2bHyQPvL-AkJKcsfvJAaY5y1BGD5OfH5yqtAzWeWBroHuw1cFZUCsXtNHfRdC2B3YI0nbKj_tf4ySOOrSg1U2rfAC1NUZLoxY-6G4wMaZvQGtdF1MDRm2V8eD3j18AYbA6P16_AgJsnPUbJYPeKiBtZAPwYaiuHib3amG8ejT9j5Lzt28-n75frM_erU5P1gvJChwWRBY0p0xCATNEsJAYyQqSmqgyr1RV5KyEBaWqLjAUVVUpiEqYo2gRjlECkqPk6U53Y6znk5eeI5YRhDFK80isdkRlxQXfON0Jd8Wt0PzvgnUNF9GjWDaHaSrTqM9SSlIIZZGVqMYMUUERgSWNWq-n04ayU5VUfXDCzETnO71ueWO3PCUFhTmJAi8mAWcvh-g577SXyhjRKzvs8iYZZnjM-9k_6O3VTVQjYgG6r208V46i_CTFGGJGSBGp5S1U_CrVaRlvt9ZxfRbwchYQmaC-hUYM3vPVp4__z559mbPP99hWCRNab80wvk4_B9MdKOMD807VNyYjyMe-uXaDj33Dp76JYU_2L-gm6LpRyB_TKBRW</recordid><startdate>20150413</startdate><enddate>20150413</enddate><creator>Huang, Lina N</creator><creator>Jun, Sunny H</creator><creator>Drubach, Nathalie</creator><creator>Dahan, Michael H</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150413</creationdate><title>Predictors of in vitro fertilization outcomes in women with highest follicle-stimulating hormone levels ≥ 12 IU/L: a prospective cohort study</title><author>Huang, Lina N ; Jun, Sunny H ; Drubach, Nathalie ; Dahan, Michael H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3c95856c0a07132ac21cd03f3eb8ded986b0955ef920addde01b081789256ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Cohort analysis</topic><topic>Embryos</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fertility clinics</topic><topic>Fertilization</topic><topic>Fertilization in Vitro</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle-stimulating hormone</topic><topic>Follicles</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>In vitro methods and tests</topic><topic>Infertility</topic><topic>Metaphase</topic><topic>Oocytes</topic><topic>Ovarian Reserve</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Prospective Studies</topic><topic>Stimulation</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Lina N</creatorcontrib><creatorcontrib>Jun, Sunny H</creatorcontrib><creatorcontrib>Drubach, Nathalie</creatorcontrib><creatorcontrib>Dahan, Michael H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale in Context : Opposing Viewpoints</collection><collection>Science (Gale in Context)</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Lina N</au><au>Jun, Sunny H</au><au>Drubach, Nathalie</au><au>Dahan, Michael H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of in vitro fertilization outcomes in women with highest follicle-stimulating hormone levels ≥ 12 IU/L: a prospective cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-13</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0124789</spage><epage>e0124789</epage><pages>e0124789-e0124789</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The purpose of this study is to evaluate factors predictive of outcomes in women with highest follicle-stimulating hormone (FSH) levels ≥ 12 IU/L on basal testing, undergoing in vitro fertilization (IVF).
A prospective cohort study was conducted at Stanford University Hospital in the Reproductive Endocrinology and Infertility Center for 12 months. Women age 21 to 43 undergoing IVF with highest FSH levels on baseline testing were included. Donor/Recipient and frozen embryo cycles were excluded from this study. Prognostic factors evaluated in association with clinical pregnancy rates were type of infertility diagnosis and IVF stimulation parameters.
The current study found that factors associated with clinical pregnancy were: increased number of mature follicles on the day of triggering, number of oocytes retrieved, number of Metaphase II oocytes if intracytoplasmic sperm injection was done, and number of embryos developed 24 hours after retrieval.
Our findings suggest that it would be beneficial for women with increased FSH levels to attempt a cycle of IVF. Results of ovarian stimulation, especially embryo quantity appear to be the best predictors of IVF outcomes and those can only be obtained from a cycle of IVF. Therefore, increased basal FSH levels should not discourage women from attempting a cycle of IVF.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25867175</pmid><doi>10.1371/journal.pone.0124789</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis Cohort analysis Embryos Endocrinology Female Fertility clinics Fertilization Fertilization in Vitro Follicle Stimulating Hormone - blood Follicle-stimulating hormone Follicles Humans In vitro fertilization In vitro methods and tests Infertility Metaphase Oocytes Ovarian Reserve Pregnancy Pregnancy Rate Prospective Studies Stimulation Women |
| title | Predictors of in vitro fertilization outcomes in women with highest follicle-stimulating hormone levels ≥ 12 IU/L: a prospective cohort study |
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