Relevance of vitamin D receptor target genes for monitoring the vitamin D responsiveness of primary human cells

Vitamin D3 has transcriptome- and genome-wide effects and activates, via the binding of its metabolite 1α,25-dihydroxyvitamin D3 to the transcription factor vitamin D receptor (VDR), several hundred target genes. Using samples from a 5-month vitamin D3 intervention study (VitDmet), we recently repor...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0124339-e0124339
Hauptverfasser:	Vukić, Maja, Neme, Antonio, Seuter, Sabine, Saksa, Noora, de Mello, Vanessa D F, Nurmi, Tarja, Uusitupa, Matti, Tuomainen, Tomi-Pekka, Virtanen, Jyrki K, Carlberg, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis B cells Bcl-6 protein Biomarkers - metabolism CD14 antigen Chromatin Immunoprecipitation Dietary Supplements Female Gene expression Gene Expression Regulation - drug effects Gene Regulatory Networks Genes Genomes Genomics Human behavior Humans In vivo methods and tests Intervention Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Middle Aged Monitoring Multigene Family Parameter identification Parathyroid Parathyroid hormone Peripheral blood mononuclear cells Real-Time Polymerase Chain Reaction Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism RNA Self organizing maps Serum levels Signal Transduction - drug effects Supplementation Supplements Transcription activation Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D Deficiency - drug therapy Vitamin D Deficiency - genetics Vitamin D Deficiency - metabolism Vitamin D receptors Vitamin D3 Vitamins - administration & dosage
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