Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China
Elevated heavy metals and fasting plasma glucose (FPG) levels were both associated with increased risk of cardiovascular diseases. However, studies on the associations of heavy metals and essential elements with altered FPG and diabetes risk were limited or conflicting. The objective of this study w...
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| creator | Feng, Wei Cui, Xiuqing Liu, Bing Liu, Chuanyao Xiao, Yang Lu, Wei Guo, Huan He, Meian Zhang, Xiaomin Yuan, Jing Chen, Weihong Wu, Tangchun |
| description | Elevated heavy metals and fasting plasma glucose (FPG) levels were both associated with increased risk of cardiovascular diseases. However, studies on the associations of heavy metals and essential elements with altered FPG and diabetes risk were limited or conflicting. The objective of this study was to evaluate the potential associations of heavy metals and essential trace elements with FPG and diabetes risk among general Chinese population.
We conducted a cross-sectional study to investigate the associations of urinary concentrations of 23 metals with FPG, impaired fasting glucose (IFG) and diabetes among 2242 community-based Chinese adults in Wuhan. We used the false discovery rate (FDR) method to correct for multiple hypothesis tests.
After adjusting for potential confounders, urinary aluminum, titanium, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, antimony, barium, tungsten and lead were associated with altered FPG, IFG or diabetes risk (all P< 0.05); arsenic was only dose-dependently related to diabetes (P< 0.05). After additional adjustment for multiple testing, titanium, copper, zinc, selenium, rubidium, tungsten and lead were still significantly associated with one or more outcomes (all FDR-adjusted P< 0.05).
Our results suggest that multiple metals in urine are associated with FPG, IFG or diabetes risk. Because the cross-sectional design precludes inferences about causality, further prospective studies are warranted to validate our findings. |
| doi_str_mv | 10.1371/journal.pone.0123742 |
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We conducted a cross-sectional study to investigate the associations of urinary concentrations of 23 metals with FPG, impaired fasting glucose (IFG) and diabetes among 2242 community-based Chinese adults in Wuhan. We used the false discovery rate (FDR) method to correct for multiple hypothesis tests.
After adjusting for potential confounders, urinary aluminum, titanium, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, antimony, barium, tungsten and lead were associated with altered FPG, IFG or diabetes risk (all P< 0.05); arsenic was only dose-dependently related to diabetes (P< 0.05). After additional adjustment for multiple testing, titanium, copper, zinc, selenium, rubidium, tungsten and lead were still significantly associated with one or more outcomes (all FDR-adjusted P< 0.05).
Our results suggest that multiple metals in urine are associated with FPG, IFG or diabetes risk. Because the cross-sectional design precludes inferences about causality, further prospective studies are warranted to validate our findings.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0123742</identifier><identifier>PMID: 25874871</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Aged ; Aluminum ; Antimony ; Arsenic ; Barium ; Blood Glucose - analysis ; Cadmium ; Cardiovascular diseases ; China ; Cobalt ; Copper ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Diabetes Mellitus - urine ; Education ; Environmental health ; Environmental protection ; Epidemiology ; False Positive Reactions ; Fasting ; Female ; Glucose ; Glucose Tolerance Test ; Health risks ; Heart diseases ; Heavy metals ; Humans ; Insulin ; Laboratories ; Laboratory testing ; Male ; Metabolism ; Metal concentrations ; Metals ; Metals, Heavy - blood ; Metals, Heavy - urine ; Middle Aged ; Molybdenum ; Nickel ; Odds Ratio ; Outdoor air quality ; Plasma ; Population ; Population studies ; Population-based studies ; Public health ; Quality Control ; Risk ; Risk Factors ; Rubidium ; Science ; Selenium ; Strontium ; Studies ; Titanium ; Trace elements ; Trace Elements - blood ; Trace Elements - urine ; Trace metals ; Tungsten ; Urine ; Zinc</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0123742-e0123742</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Feng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Feng et al 2015 Feng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-1d5c57cd80c04e602fb5ffd184780bad15ec563ea65542b4c6de0adf06df3d023</citedby><cites>FETCH-LOGICAL-c585t-1d5c57cd80c04e602fb5ffd184780bad15ec563ea65542b4c6de0adf06df3d023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395404/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395404/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25874871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Wei</creatorcontrib><creatorcontrib>Cui, Xiuqing</creatorcontrib><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Liu, Chuanyao</creatorcontrib><creatorcontrib>Xiao, Yang</creatorcontrib><creatorcontrib>Lu, Wei</creatorcontrib><creatorcontrib>Guo, Huan</creatorcontrib><creatorcontrib>He, Meian</creatorcontrib><creatorcontrib>Zhang, Xiaomin</creatorcontrib><creatorcontrib>Yuan, Jing</creatorcontrib><creatorcontrib>Chen, Weihong</creatorcontrib><creatorcontrib>Wu, Tangchun</creatorcontrib><title>Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Elevated heavy metals and fasting plasma glucose (FPG) levels were both associated with increased risk of cardiovascular diseases. However, studies on the associations of heavy metals and essential elements with altered FPG and diabetes risk were limited or conflicting. The objective of this study was to evaluate the potential associations of heavy metals and essential trace elements with FPG and diabetes risk among general Chinese population.
We conducted a cross-sectional study to investigate the associations of urinary concentrations of 23 metals with FPG, impaired fasting glucose (IFG) and diabetes among 2242 community-based Chinese adults in Wuhan. We used the false discovery rate (FDR) method to correct for multiple hypothesis tests.
After adjusting for potential confounders, urinary aluminum, titanium, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, antimony, barium, tungsten and lead were associated with altered FPG, IFG or diabetes risk (all P< 0.05); arsenic was only dose-dependently related to diabetes (P< 0.05). After additional adjustment for multiple testing, titanium, copper, zinc, selenium, rubidium, tungsten and lead were still significantly associated with one or more outcomes (all FDR-adjusted P< 0.05).
Our results suggest that multiple metals in urine are associated with FPG, IFG or diabetes risk. Because the cross-sectional design precludes inferences about causality, further prospective studies are warranted to validate our findings.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Aluminum</subject><subject>Antimony</subject><subject>Arsenic</subject><subject>Barium</subject><subject>Blood Glucose - analysis</subject><subject>Cadmium</subject><subject>Cardiovascular diseases</subject><subject>China</subject><subject>Cobalt</subject><subject>Copper</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - blood</subject><subject>Diabetes Mellitus - urine</subject><subject>Education</subject><subject>Environmental health</subject><subject>Environmental protection</subject><subject>Epidemiology</subject><subject>False Positive Reactions</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose Tolerance Test</subject><subject>Health risks</subject><subject>Heart diseases</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Insulin</subject><subject>Laboratories</subject><subject>Laboratory testing</subject><subject>Male</subject><subject>Metabolism</subject><subject>Metal concentrations</subject><subject>Metals</subject><subject>Metals, Heavy - blood</subject><subject>Metals, Heavy - urine</subject><subject>Middle Aged</subject><subject>Molybdenum</subject><subject>Nickel</subject><subject>Odds Ratio</subject><subject>Outdoor air quality</subject><subject>Plasma</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Public health</subject><subject>Quality Control</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Rubidium</subject><subject>Science</subject><subject>Selenium</subject><subject>Strontium</subject><subject>Studies</subject><subject>Titanium</subject><subject>Trace elements</subject><subject>Trace Elements - blood</subject><subject>Trace Elements - urine</subject><subject>Trace metals</subject><subject>Tungsten</subject><subject>Urine</subject><subject>Zinc</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkl2LEzEUhgdR3HX1H4gGBPGmNd-Z7oVQih8LC97odcgkZ9rUdDImMyv7703b2aUVrxKS57zv-aqq1wTPCVPk4zaOqTNh3scO5phQpjh9Ul2SBaMzSTF7enK_qF7kvMVYsFrK59UFFbXitSKX1d0y52i9GXzsUGzRmHxn0j3awWAC6lNsfYCM_vhhg0wYIIFD6zDamAEFuIOQkekcct40MBQw-fzrGhnUx34MB9VZY3IJysPo7pHv0GpTHF5Wz1oTMryazqvq55fPP1bfZrffv96slrczK2oxzIgTVijramwxB4lp24i2daTmqsaNcUSAFZKBkUJw2nArHWDjWixdyxym7Kp6e9TtQ8x6alnWRCpGKCFKFeLmSLhotrpPflfK19F4fXiIaa1NGrwNoKWwJRALaQXmTokFt4wualNLRYq_K1qfJrex2YGz0A3JhDPR85_Ob_Q63mnOFoJjXgQ-TAIp_h4hD3rns4UQTAdxPOTN5QJTLAv67h_0_9VN1NqUAnzXxuJr96J6ySnFVDJGCvX-hNpAGfQmxzDux5fPQX4EbYo5J2gfayNY77fyIQm930o9bWUJe3Pal8eghzVkfwGMgd9k</recordid><startdate>20150413</startdate><enddate>20150413</enddate><creator>Feng, Wei</creator><creator>Cui, Xiuqing</creator><creator>Liu, Bing</creator><creator>Liu, Chuanyao</creator><creator>Xiao, Yang</creator><creator>Lu, Wei</creator><creator>Guo, Huan</creator><creator>He, Meian</creator><creator>Zhang, Xiaomin</creator><creator>Yuan, Jing</creator><creator>Chen, Weihong</creator><creator>Wu, Tangchun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150413</creationdate><title>Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China</title><author>Feng, Wei ; Cui, Xiuqing ; Liu, Bing ; Liu, Chuanyao ; Xiao, Yang ; Lu, Wei ; Guo, Huan ; He, Meian ; Zhang, Xiaomin ; Yuan, Jing ; Chen, Weihong ; Wu, Tangchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-1d5c57cd80c04e602fb5ffd184780bad15ec563ea65542b4c6de0adf06df3d023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Aluminum</topic><topic>Antimony</topic><topic>Arsenic</topic><topic>Barium</topic><topic>Blood Glucose - analysis</topic><topic>Cadmium</topic><topic>Cardiovascular diseases</topic><topic>China</topic><topic>Cobalt</topic><topic>Copper</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - blood</topic><topic>Diabetes Mellitus - urine</topic><topic>Education</topic><topic>Environmental health</topic><topic>Environmental protection</topic><topic>Epidemiology</topic><topic>False Positive Reactions</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose Tolerance Test</topic><topic>Health risks</topic><topic>Heart diseases</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Insulin</topic><topic>Laboratories</topic><topic>Laboratory testing</topic><topic>Male</topic><topic>Metabolism</topic><topic>Metal concentrations</topic><topic>Metals</topic><topic>Metals, Heavy - blood</topic><topic>Metals, Heavy - urine</topic><topic>Middle Aged</topic><topic>Molybdenum</topic><topic>Nickel</topic><topic>Odds Ratio</topic><topic>Outdoor air quality</topic><topic>Plasma</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Public health</topic><topic>Quality Control</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Rubidium</topic><topic>Science</topic><topic>Selenium</topic><topic>Strontium</topic><topic>Studies</topic><topic>Titanium</topic><topic>Trace elements</topic><topic>Trace Elements - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Wei</au><au>Cui, Xiuqing</au><au>Liu, Bing</au><au>Liu, Chuanyao</au><au>Xiao, Yang</au><au>Lu, Wei</au><au>Guo, Huan</au><au>He, Meian</au><au>Zhang, Xiaomin</au><au>Yuan, Jing</au><au>Chen, Weihong</au><au>Wu, Tangchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-13</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0123742</spage><epage>e0123742</epage><pages>e0123742-e0123742</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Elevated heavy metals and fasting plasma glucose (FPG) levels were both associated with increased risk of cardiovascular diseases. However, studies on the associations of heavy metals and essential elements with altered FPG and diabetes risk were limited or conflicting. The objective of this study was to evaluate the potential associations of heavy metals and essential trace elements with FPG and diabetes risk among general Chinese population.
We conducted a cross-sectional study to investigate the associations of urinary concentrations of 23 metals with FPG, impaired fasting glucose (IFG) and diabetes among 2242 community-based Chinese adults in Wuhan. We used the false discovery rate (FDR) method to correct for multiple hypothesis tests.
After adjusting for potential confounders, urinary aluminum, titanium, cobalt, nickel, copper, zinc, selenium, rubidium, strontium, molybdenum, cadmium, antimony, barium, tungsten and lead were associated with altered FPG, IFG or diabetes risk (all P< 0.05); arsenic was only dose-dependently related to diabetes (P< 0.05). After additional adjustment for multiple testing, titanium, copper, zinc, selenium, rubidium, tungsten and lead were still significantly associated with one or more outcomes (all FDR-adjusted P< 0.05).
Our results suggest that multiple metals in urine are associated with FPG, IFG or diabetes risk. Because the cross-sectional design precludes inferences about causality, further prospective studies are warranted to validate our findings.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25874871</pmid><doi>10.1371/journal.pone.0123742</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-04, Vol.10 (4), p.e0123742-e0123742 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1673121177 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Adults Aged Aluminum Antimony Arsenic Barium Blood Glucose - analysis Cadmium Cardiovascular diseases China Cobalt Copper Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - urine Education Environmental health Environmental protection Epidemiology False Positive Reactions Fasting Female Glucose Glucose Tolerance Test Health risks Heart diseases Heavy metals Humans Insulin Laboratories Laboratory testing Male Metabolism Metal concentrations Metals Metals, Heavy - blood Metals, Heavy - urine Middle Aged Molybdenum Nickel Odds Ratio Outdoor air quality Plasma Population Population studies Population-based studies Public health Quality Control Risk Risk Factors Rubidium Science Selenium Strontium Studies Titanium Trace elements Trace Elements - blood Trace Elements - urine Trace metals Tungsten Urine Zinc |
| title | Association of urinary metal profiles with altered glucose levels and diabetes risk: a population-based study in China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T14%3A41%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20urinary%20metal%20profiles%20with%20altered%20glucose%20levels%20and%20diabetes%20risk:%20a%20population-based%20study%20in%20China&rft.jtitle=PloS%20one&rft.au=Feng,%20Wei&rft.date=2015-04-13&rft.volume=10&rft.issue=4&rft.spage=e0123742&rft.epage=e0123742&rft.pages=e0123742-e0123742&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0123742&rft_dat=%3Cgale_plos_%3EA422026331%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1673121177&rft_id=info:pmid/25874871&rft_galeid=A422026331&rft_doaj_id=oai_doaj_org_article_65c167056c504d7594c3298a8671554d&rfr_iscdi=true |