A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis

Spermatogenesis is an elaborately regulated system dedicated to the continuous production of spermatozoa via the genesis of spermatogonia. In this process, a variety of genes are expressed that are relevant to the differentiation of germ cells at each stage. Although Notch signaling plays a critical...

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Veröffentlicht in:	PloS one 2015-04, Vol.10 (4), p.e0124293-e0124293
Hauptverfasser:	Okuda, Hidenobu, Kiuchi, Hiroshi, Takao, Tetsuya, Miyagawa, Yasushi, Tsujimura, Akira, Nonomura, Norio, Miyata, Haruhiko, Okabe, Masaru, Ikawa, Masahito, Kawakami, Yoshitaka, Goshima, Naoki, Wada, Morimasa, Tanaka, Hiromitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biomarkers Cell Differentiation Cell Line Cell Nucleus - metabolism Co-Repressor Proteins - genetics Co-Repressor Proteins - metabolism Continuous production Differentiation Fruit flies Genes Genetic aspects Germ Cells - cytology Germ Cells - metabolism HEK293 Cells Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Infectious diseases Infertility Ligands Male Mammals Medicine Mice Mice, Inbred ICR Molecular biology Notch protein Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Pharmaceutical sciences Phenotype Protein Binding Proteins Real-Time Polymerase Chain Reaction Receptors, Notch - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Messenger - metabolism Rodents Signal Transduction Signaling Sperm Spermatogenesis Spermatozoa Spermatozoa - metabolism Stem cells Testes Testis - metabolism Testis - pathology Transcription (Genetics) Transcription Factor HES-1 Transfection University graduates Urology
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